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出 处:《中华老年医学杂志》2012年第10期854-856,共3页Chinese Journal of Geriatrics
摘 要:目的观察舒芬太尼复合七氟醚用于老年患者麻醉诱导时的临床效果。方法选择择期行腹部手术患者84例,根据七氟醚麻醉诱导时舒芬太尼不同用量,随机分为4组,A组舒芬太尼剂量为0.25μg/kg,B组0.05μg/kg,C组0.75μg/kg,D组1.00μg/kg,每组21例。记录患者进入手术室后10min(T0)、插管前即刻(T1)、插管后即刻(T2)、插管后1min(Ts)、3min(Tt)、5rain(Ts)的平均动脉压(MAP)和心率,并对各组的插管条件进行评分。结果拔管后10min、30min、60min视觉模拟评分(VAs)A组分别为(4.2±0.9、3.5±0.7、4.2±0.4)分,B组分别为(4.0±0.4、3.2±0.8、3.8±0.7)分,c组分别为(3.4±1.0、1.7±1.4、2.6±0.6)分,D组分别为(2.7±0.2、1.9±0.4、1.7±0.8)分;Ramsay评分A组分别为(1.4±1.1、0.8±0.1、2.8±0.1)分,B组分别为(2.2±2.3、1.3±0.4、2.2±0.2)分,C组分别为(2.8±1.7、1.9±0.1、2.0±0.1)分,D组分别为(3.7±2.0、2.4±0.6、2.9±0.1)分;4组患者拔管后各时点,VAS和Ramsay评分为D组〉C组〉B组〉A组(F=5.78,P〈0.05)。T0、T1、T2、T3、T4、T5时点平均动脉压(MAP)A组分别为(93.8±8.1、82.1±4.3、92.8±5.9、90.1±4.8、85.3±4.2、78.0±3.5)mmHg,B组分别为(91.8±6.8、83.4±4.5、87.2±5.1、84.2±5.2、85.6±2.8、84.4±3.6)mmHg,C组分别为(92.8±5.2、82.1±6.0、80.1±4.2、78.0±2.9、75.4±3.3、65.4±5.2)mmHg,D组分别为(88.5±6.3、75.9±4.5、80.1±2.8、76.1±2.3、69.3土3.8、68.9±4.9)mmHg;心率A组分别为(74.2±2.3、68.8±4.9、82.4±4.2、86.4±3.7、80.2±5.1、67.2±4.7)次/min,B组分别为(75.6±1.2、63.8±5.9、78.2±3.9、79.3±5.6、76.3±6.7、64.8±3Objective To observe the clinical effects of sufentanil combined with sevoflurane for anesthesia induction in the elderly. Methods A total of 84 patients undergoing elective laparoscopic were randomly divided into 4 groups by dose of Sufentanil ( 21 eases, each) 0.25, 0.50, 0.75 and 1.00 μg/kg sufentanil. Mean arterial pressure (MAP)and heart rate (HR)were measured at baseline (To), immediately before intubation(T1), immediately, 1, 3 and 5 min after intubation (T2-5). Intubation scores were also recorded. Results The intubation scores including visual analogue score (VAS) and Ramsay score at 10 min, 30 min and 60 min after tube drawing were as the following sequence: 1.0 μg/kg :〉0.75 μg/kg :〉0.5μg/kg ~0.25 txg/kg sufentanil (F= 5.78,P^0.05). Compared with TO, MAP and HR decreased in each group at T1, while increased at T2 in group A (P d0.05). As compared with TO, MAP was decreased and HR was slower at T1 in the 4 groups (F= 34.99,P^0.05), but MAP level was increased in 0.25 /~g/kg sufentanil group at T2 (F= 12.48,P~ 0.05). Compared with group of 0.25 ~g/kg sufentanil, MAP was reduced in 0.75μg/kg and 1.00 gg/ kg groups at T4 and T5 (F=6.98,6.25,P^0.05). MAP was also lower in 0.75 μg/kg and 1.00 μg/ kg groups than in 0.50/xg/kg sufentanil group at T2-TS(F=7.08,20.56,P-0.05). Conclusions Sufentanil of 0.25 0.50 μg/kg combined with sevoflurane can provide excellent intubating conditions and stable hemodynamics during anesthesia induction in patients undergoing gynecologic surgery.
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