三种高脂乳剂诱导实验性大鼠高脂血症模型的比较  

Comparison of Experimental Hyperlipidemia Rat Model Induced by Three Kinds of Lipid Emulsion

作　　者：石鹤坤[1] 张宏[2] 杜青云[1] 陈锦珊[1] 

机构地区：[1]解放军第175医院/厦门大学附属东南医院药剂科,漳州363000 [2]辽宁省中医药研究院,沈阳110034

出　　处：《中国比较医学杂志》2012年第9期55-57,共3页Chinese Journal of Comparative Medicine

摘　　要：目的探索理想的大鼠高脂血症动物模型造模方法。方法参考文献改进3种大鼠高脂配方,并制成高脂乳剂给大鼠灌胃,14 d后眦内静脉取血测定血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)的含量。结果三种高脂配方均不同程度的使大鼠血清中脂代谢紊乱。结论高脂配方3可在短时间内形成高脂血症大鼠模型。Objective To explore the ideal experimental rats model for research on hyperlipidemia. Methods Three prescriptions on experimental hyperlipidemia-rats were modified and emulsion was made by references. At 14 day blood samples were taken from ocular orbit and content of TC.TG.LDL.HDL in the serum were measured. Results Three prescriptions could lead to the disorder of lipid metabolism at different levels. Conclusion Hyperlipidemia-rats model can be formed in a short time by prescription 3.

关 键 词：高脂血症 大鼠 模型 

分 类 号：R332[医药卫生—人体生理学]