辅酶Q10治疗蒽环类药物致心脏毒性的疗效  

Coenzyme Q10(CoQ10) reduce the heart toxicity caused by anthracycline-based chemotherapy drugs

作　　者：孙玉书[1] 高德荣[1] 

机构地区：[1]内蒙古医学院附属人民医院肿瘤科,内蒙古呼和浩特010020

出　　处：《现代肿瘤医学》2012年第10期2159-2161,共3页Journal of Modern Oncology

摘　　要：目的:研究辅酶Q10(CoQ10)对使用蒽环类化疗药物致心脏毒性的保护作用,并探讨可能的机理。方法:60例肿瘤患者随机分为治疗组(30例)和对照组(30例),化疗同时分别予CoQ10及大剂量维生素E治疗,治疗前后行心电图、心肌酶检查。结果:化疗后CoQ10组心电图和血清心肌酶学指标均优于对照组(P<0.05)。结论:CoQ10对蒽环类化疗药物所致心脏毒性有保护作用。Objective：To study the protective effect of CoQ10 on the cardiovascular toxicity induced by anthracycline,and investigate the possible mechanisms.Methods：Sixty tumor patients were randomly divided into treatment group（30 cases） and control group（30 cases）.Receiving chemotherapy,at the same time,CoQ10 and a large dose of vitamin E were given in two groups.Electrocardiography and cardiac enzymes were examined before and after treatment.Results： ECG and myocardial enzyme were all improved significantly in the treatment group,and the changes were superior to those of the control group（P0 05）.Conclusion：CoQ10 had protective effects on the cardiovascular toxicity induced by anthracycline.

关 键 词：辅酶Q10 蒽环类药物 心脏毒性 

分 类 号：R979.1[医药卫生—药品]