阿昔洛韦药物树脂复合物体外释药动力学的研究  

Release kinetics of aciclovir resinate in vitro

作　　者：刘宏飞[1,2] 师双双[1] 赵欣[1] 申升[1] 何浩[1] 黄鸿飞[1] 高丽[1] 潘卫三[2] 

机构地区：[1]江苏大学药学院,镇江212013 [2]沈阳药科大学药学院,沈阳110016

出　　处：《中国新药杂志》2012年第18期2205-2208,共4页Chinese Journal of New Drugs

基　　金：辽宁省教育厅创新团队项目(2006T127)

摘　　要：目的:制备阿昔洛韦药物树脂复合物并对其体外释药动力学进行考察。方法:以静态交换法制备了阿昔洛韦药物树脂复合物并对阿昔洛韦药物树脂在不同溶出介质中的释药动力学进行了考察。结果:体外释药动力学研究表明,阿昔洛韦药物树脂的释药速率随着溶出介质中离子强度的增大、温度的升高而加快,且释药速率与反离子种类有关。结论:阿昔洛韦药物树脂的释药速率与溶出介质的离子强度、反离子种类和温度有关。I Objective： To prepare the resinate in vitro. Methods： The drug-resinates aciclovir resinates and investigate were made by a bath method. The the release kinetics of the drugdrug release kinetics was also investigated in different releasing mediums. Results： The release rate increased with increasing ionic strength in the release mediums and the rise in temperature. The release rate changed with the counter-ion type. Conclusion： The release rate of the drug-resinates is correlated with ionic strength in the release mediums, the type of counter-ion and temperature.

关 键 词：阿昔洛韦 离子交换树脂 离子交换反应 释药动力学 缓释制剂 

分 类 号：R943.41[医药卫生—药剂学] R978.7[医药卫生—药学]