中国以前列腺体积增大为特点的良性前列腺增生症患者的临床特点  

Investigation of the clinical characteristics of benign prostatic hyperplasia patients with enlarged prostate in China

作　　者：张耀光[1] 王建业[1] 万奔[1] 魏东[1] 刘明[1] 许进[1] 伍建业[1] 褚欣[1] 张亚群[1] 王鑫[1] 

机构地区：[1]卫生部北京医院泌尿科,100730

出　　处：《中华泌尿外科杂志》2012年第10期782-785,共4页Chinese Journal of Urology

摘　　要：目的多中心调查中国以前列腺体积增大为特点的中、重度BPH患者在现实状况下的临床诊疗特点。方法2009年2月至2011年1月，全国10个城市的32家医院共纳入前列腺体积≥30ml且IPSS≥8的BPH患者2758例。在不干预医生、患者正常诊疗措施的情况下，记录患者的年龄、前列腺体积（prostatevolume，PV）、IPSS评分、Q、服药情况和医生处方习惯，分析患者的人口学信息和临床特点。结果患者年龄50～97岁，平均（69．2±8．5）岁，经直肠超声检查测量PV为30～165ml，平均（47．8±16．6）ml，IPSS为8～35分，平均（17．5±5．4）分，Q…为2～36ml／s，平均（11．6±3．6）ml／s。以年龄为分层指标，亚组分析结果显示：50～55岁组平均PV、Q…分别是42．8ml、13．3ml／s，〉71岁组平均PV、Q为49．0ml、11．1ml／s，两组比较差异有统计学意义（P值均〈0．05）。人组患者中56．1％为初次就诊，规律服用处方药物〉2周者仅为22．8％。入组时已有BPH症状〈1年者仅为31．3％（872例），1～2、3～4和≥5年者分别占22．9％（637例）、18．3％（311例）和27．5％（766例）。医生处方采用指南推荐的5-a还原酶抑制剂和0【受体阻滞剂联合治疗仅为52．6％。结论我国中、重度BPH患者的症状和主要客观指标随年龄增长而加重，绝大多数患者初次就诊时机偏晚。医生的处方习惯与指南推荐还有很大的差距。Objective To evaluate the real-life clinical characteristics of benign prostatic hyperpla- sia （BPH） patients with moderate and severe enlarged prostate. Methods From February 2009 to Janu- ary 2011, a prospective, non-interventional, multi-center study was conducted on 2 758 BPH patients re- cruited from 32 hospitals in 10 cities nationwide with the following criteria： prostate volume （PV） larger ≥ 30 ml and international prostate symptom score （IPSS） t〉 8. Patient age, PV, IPSS, Q medical treat- ment patterns and physician prescription practice were recorded. The demographic information and clinic characteristics were evaluated as well. Results The mean patient age, PV, IPSS score and Qma, of 2 786 eligible patients were 69.2 ± 8.5 years （50 to 97 years）, 47.8 ＋ 16.6 ml （30 to 165 ml） , 17.5 ± 5.4 （8 to 35） and 11.6 ＋3.6 ml/s （2 to 36 ml/s） , respectively. Age subgroup analysis pointed that the mean PV and Q in 50 -55 years group were 42.8 ml and 13.3 ml/s compared to 49.0 ml and 11.1 ml/s in the group beyond 71 years. Both parameters had statistical significances （P 〈 0.05 ）. For 56. 1% of the pa- tients, it was their first time coming to clinic seeking for medical advice. Of whom, 22.8% patients had taken BPH prescription medication regularly beyond two weeks. Only 31.3% of the patients had a history of BPH shorter than one year. 22.9% and 18.3% of the patients had a history of BPH for 1 - 2 and 3 - 4 years. And 27.5% of the patients had a history of BPH related symptoms longer than five years. Only 52.6% patients were treated with ct adrenoceptor antagonists ＋ 5-or reductase inhibitor by urologists accord- ing to the recommendation in Chinese guideline of BPH. Conclusions The symptoms and key parameters of moderate and severe benign prostatic hyperplasia （BPH） patients become worse and more with increased age in China. It is quite late for most patients coming to clinic seeking for their first medical advice. Further- more, there is a huge gap between urolo

关 键 词：良性前列腺增生 诊疗模式 临床特点 中国 

分 类 号：R697.3[医药卫生—泌尿科学]