反应时间对复方硼砂溶液制备工艺的影响  

Effects of Reaction Time on Preparation Technology of Compound Borax Solution

作　　者：马亮英[1] 蒋磊[2] 林伊梅[1] 李宏智[1] 

机构地区：[1]新疆医科大学第二附属医院药剂科,乌鲁木齐830028 [2]新疆医科大学附属肿瘤医院药剂科,乌鲁木齐830011

出　　处：《中国药房》2012年第41期3904-3905,共2页China Pharmacy

摘　　要：目的:确定复方硼砂溶液制备过程中的反应时间。方法:按照复方硼砂溶液的制备工艺,分别考察A液与B液室温下混合反应不同时间(0、30、35、45、60、120、150、180、240、270、720、1440min)后制备的样品中的3组分即碳酸氢钠、苯酚和硼砂含量的变化,确定完成反应的时间并进行工艺验证。结果:室温25℃下反应240～1440min内的样品中3组分的含量前后比较均无显著性差异,工艺验证中3批样品中各组分含量均符合规定。结论:复方硼砂溶液制备中A液与B液反应时间以240min为宜。OBJECTIVE： To determine the reaction time of Compound borax solution during preparation process. METHODS： According to preparation technology of Compound borax solution, the content change of 3 components, ie. dicarbonate, phenol and borax in solution A and solution B were investigated after 0, 30, 35, 45, 60, 120, 150, 180, 240, 270, 720 and 1 440 min. The reaction time was determined and preparation technology was validated. RESULTS： The contents of 3 components in samples had no significant difference before and after the reaction time of 240 to 1 440 min at 25 ℃. In validation test, the contents of com- ponents in 3 batches of samples were in line with the standard. CONCLUSION： For the preparation of Compound borax solution, the reaction time of solution A and B is 240min probably.

关 键 词：复方硼砂溶液 制备 反应时间 工艺验证 

分 类 号：R943[医药卫生—药剂学]