含硼类抗感染药物的研究进展  

Research progress of boron-containing compounds as anti-infective drugs

作　　者：李清[1] 周金培[1] 王帅[1] 张惠斌[1] 

机构地区：[1]中国药科大学新药研究中心,南京210009

出　　处：《中国新药杂志》2012年第19期2257-2264,共8页Chinese Journal of New Drugs

基　　金：江苏省产学研联合创新资金--前瞻性联合研究(BY2011158);中央高校基本科研业务费专项基金(JKY2011099)

摘　　要：随着化学治疗药物的广泛使用,微生物对药物产生的耐药性已经成为全球严重的公共卫生问题。寻找具有新结构和新的作用机制的药物是克服耐药的主要办法之一。硼具有与其他元素不同的独特性质,含硼化合物增加了分子结构的多样性。这类化合物以其全新的结构和特殊的作用机制,成为药物研发的新途径。本文综述了含硼类抗感染药物的研发进展。With the widespread use of chemotherapeutial agents, microbial resistance to drugs has become a serious global problem of public health. Looking for drugs with novel structures and action mechanisms is one of the major approaches to overcome resistance. Boron has unique characteristics that differ from other elements, and boron-containing compounds expand molecular diversity. These compounds with novel structures and special action mechanisms have become a new way of drug research and development. In this paper, we introduced the research progress of boron-containing compounds as anti-infective drugs.

关 键 词：含硼化合物 化学治疗药 耐药 抗感染药物 

分 类 号：R978.1[医药卫生—药品]