可变剂量帕利哌酮缓释片对急性期精神分裂症认知功能的影响  

Cognitive effect of flexible-dose oral paliperidone extended-release tablets in treating acute schizophrenia

作　　者：陈发展[1] 周卉[2] 陆峥[2,3] 熊祥玉[2] 黄楠[2] 何磊英[2] 杨程青[2] 

机构地区：[1]同济大学医学院,上海200092 [2]上海交通大学医学院附属精神卫生中心临床精神科,上海200030 [3]同济大学附属同济医院精神医学科,上海200065

出　　处：《中国新药杂志》2012年第19期2297-2301,共5页Chinese Journal of New Drugs

摘　　要：目的:评估可变剂量的帕利哌酮缓释片对急性期精神分裂症认知功能的影响。方法:对58例急性期精神分裂症患者进行可变剂量的帕利哌酮缓释片治疗。在治疗前和8周末分别使用成套神经心理测验对认知功能进行评估,比较治疗前后认知功能的变化。结果:经过8周的治疗,简短视觉空间记忆测验、WAIS-Ⅲ符号搜索、定步调听觉连续加法测验和威斯康星卡片分类测验的结果均有显著变化,具有统计学意义(P<0.05);而Stroop色词测验和数字符号编码测验的变化没有统计学意义。霍普金斯词语学习测验除了假阳性数在8周末显著减少外(P<0.05),其他各项的变化无统计学意义。WMS-Ⅲ空间广度测验的顺行广度得分和总分在治疗前后无显著变化,但是逆行广度得分在8周末显著升高(P<0.05)。结论:可变剂量的帕利哌酮缓释片对急性期精神分裂症患者的大部分认知功能损害有改善作用。Objective： To evaluate the effect of flexible-dose oral paliperidone extended-release tablets on cognitive function in the treatment of acute schizophrenia. Methods： Totally 58 inpatients with acute schizophrenia participated in the open label trial, and were treated with flexible doses of paliperidone-ER （3 -12 mg·d^-1） for 8 weeks. The complete neuropsychological tests were used to evaluate inpatients＇ cognitive function at baseline and 8th week. Then the changes of cognitive function were compared before and after treatment. Results： After 8-week treatment, there were 51 inpatients belonging to ITT. At the end of 8th week, the scores of Wiscon Brife Visuospatial Memory Tests （BVMT-R）, Symbol Search Test, Paced Auditory Seria Addition Task （PASAT） and Wisconsin Card Sorting Test （WCST） were significantly improved （P 〈0.05）. In the analysis of Hopkins Verbal Learning Test-Revised （HVLT）, the number of false positives were notably higher than baseline （P 〈 0.05 ）, but other Out-comes were no statistically significant changes. Meanwhile there were no significant difference in the anterograde spatial span and the total scores of Spatial Span Subtest of Wechsler Memory Scale-HI between baseline and follow- up end point, and the scores of retrograde spatial span were significantly higher （ P 〈 O. 05 ）. Conclusion ： Flexi- ble-dose oral paliperidone extended-release tablets can significantly improve the most domain of cognitive function impairment in patients with acute schizophrenia.

关 键 词：帕利哌酮缓释片 精神分裂症 急性期 认知功能 开放性研究 

分 类 号：R969.4[医药卫生—药理学] R971.4[医药卫生—药学]