肝硬化患者肝纤维化与血清甲状腺激素水平关系研究  

Liver fibrosis in patients with liver cirrhosis was negatively correlated to thyroid function

作　　者：郄会卿[1] 刘翠清[1] 王春秀[1] 

机构地区：[1]河北医科大学中医院检验科,河北石家庄050011

出　　处：《现代预防医学》2012年第20期5368-5369,5372,共3页Modern Preventive Medicine

摘　　要：目的探讨肝硬化患者肝纤维化与血清甲状腺激素水平的关系。方法纳入122例肝硬化患者,测定透明质酸(HA)、N端-III型前胶原氨基端肽(NT-PIIIP)、IV型胶原(C-IV)及层黏连蛋白(LN)及促甲状腺素(TSH)、游离三碘甲状腺原氨酸(FT3)及游离甲状腺素(FT4)水平,分析两者的关系;同时纳入122例健康对照。结果与健康对照相比,肝硬化患者TSH升高而FT3及FT4均下降;肝硬化患者肝纤维化程度与血清甲状腺功能呈负相关;治疗后血清甲状腺激素水平可有所升高,TSH下降。结论肝硬化患者肝纤维化程度与血清甲状腺激素呈负相关。OBJECTIVE To investigate the relationship between liver cirrhosis, liver fibrosis and serum levels thyroid hor mones. METHODS One hundred and twenty-two liver cirrhosis patients and 122 healthy controls were enrolled. Serum levels of hyaluronic acid （HA）, type-four collagen （C-IV）, collagen type III N-terminal peptide （NT-PIIIP）, and laminin （LN） were measured by ELISA. Serum levels of free triiodothyronine （FT3）, free thyroxin （FT4） and thyrotrophin （TSH） were as sayed by commercially available kits. RESULTS Compared with healthy controls, serum levels of FT3 and FF4 were lower in patients with liver cirrhosis while TSH levels were higher in these patients. Serum levels of thyroid function was negatively corre lated to fibrosis. CONCLUSION Liver fibrosis in patients with liver cirrhosis significantly is correlated to decreased thyroid function.

关 键 词：肝硬化 肝纤维化 甲状腺激素水平 

分 类 号：R657.31[医药卫生—外科学]