呋喃唑酮在多壁碳纳米管修饰电极上的电化学行为及分析应用  

Electrochemical Behavior of Furazolidone at Mulit-walled Carbon Nanotubes Modified Glassy Carbon Electrode and Its Analytical Application

作　　者：段连生[1] 张蕾[1] 

机构地区：[1]湖北第二师范学院化学与生命科学学院,湖北武汉430205

出　　处：《分析科学学报》2012年第5期673-676,共4页Journal of Analytical Science

基　　金：湖北省教育厅重点科技项目(No.D20113004);湖北第二师范学院重点学科<应用化学>项目

摘　　要：本文采用循环伏安法(CV)和差分脉冲伏安法(DPV),研究了呋喃唑酮(FZ)在多壁碳纳米管修饰玻碳电极(MWNTs/GCE)上的电化学行为。对影响该修饰电极电流大小的主要条件,如底液的pH值、富集电位和富集时间等进行了优化。结果表明:FZ在MWNTs/GCE上呈现不可逆的还原峰。与裸电极相比,FZ在修饰电极上的还原峰电流明显增大。在最佳的实验条件下,其峰电流随着FZ浓度的增加而增大,在4.9×10-7～5.9×10-5 mol.L-1范围内成线性关系,检测限低至8.0×10-8 mol.L-1。该修饰电极对FZ的测定表现出良好的重现性和稳定性,可用于药物制剂中FZ的定量测定。The electrochemical behavior of Furazolidone（FZ） at multi-walled carbon nanotube modified glassy carbon electrode （MWNTs/GCE） has been investigated by cyclic voltammetry （CV） and differential pulse voltammetry （DPV）. The effects, such as pH of supporting electrolyte, accumulation potential and accumulation time, were optimized. FZ underwent irreversible reduction at the modified electrode,which was an adsorption-controlled process. The reductive peak current of FZ significantly increased at the modified electrode compared with the bare glassy carbon electrode, suggesting that the multiwalled carbon nanotubes can enhance the electron transfer rate. The current was proportional to the concentration of FZ over 4.9 × 10^-7-5. 9 ×10 ^-5 mol. L -1 and the detection limit was calculated to be 8.0 × 10^- 8 mol.L-1. The modified electrode had excellent reproducibility and stability, and it can be used for the determination of FZ in pharmaceutical preparations.

关 键 词：呋喃唑酮 多壁碳纳米管 循环伏安法 差分脉冲伏安法 

分 类 号：O657.1[理学—分析化学]