胃肠安丸组方中枳壳大黄配伍的化学成分研究  

Changes of chemical components in compatibility of Aurantii Fructus and Rhei Radix et Rhizoma in Weichang′an Pills

作　　者：王磊[1,2] 张静泽[1] 高文远[1] 刘振[1] 

机构地区：[1]天津大学药物科学与技术学院,天津300072 [2]天津中新药业集团股份有限公司乐仁堂制药厂,天津300380

出　　处：《中成药》2012年第10期1949-1954,共6页Chinese Traditional Patent Medicine

摘　　要：目的研究枳壳大黄配伍后化学成分变化以及黄酮苷、蒽醌类成分在配伍前后含有量的差异。方法采用HPLC对药材枳壳与大黄甲醇提取物配伍前后化学成分进行分析,测定枳壳中4种黄酮苷(芸香柚皮苷、柚皮苷、橙皮苷、新橙皮苷),大黄中5种蒽醌类成分(芦荟大黄素、大黄酸、大黄素、大黄酚、大黄素甲醚)在配伍前后游离型以及结合型含有量的变化。结果指纹图谱分析结果显示枳壳大黄配伍后并未出现新的化学成分,而配伍后枳壳中黄酮苷类成分,大黄中蒽醌类成分含有量呈现不同程度的增加。结论枳壳大黄配伍促进了其有效成分黄酮苷及蒽醌类化合物的溶出。AIM To study the changes of chemical components in compatibility of Aurantii Fructus and Rhei Radix et Rhizoma in Weichang′an Pills and to determine the changes of the contents of flavones and anthraquinones after the compatibility of two herbs.METHODS HPLC was used to analyze the changes of the contents of narirutin,naringin,hesperidin and neohesperidin in Aurantii Fructus and aloe-emodin,rhein,emodin,chrysophanol and physcion in Rhei Radix et Rhizoma after compatibility.RESULTS There were few changes in chemical constituents after compatibility.However,the contents of some components such as narirutin,naringin,hesperidin and neohesperidin in Aurantii Fructus,aloe-emodin,rhein,emodin,chrysophanol and physcion in Rhei Radix et Rhizoma had the increase in different degrees after compatibility.CONCLUSION The dissolution of main chemical constituents is promoted by the compatibility of Aurantii Fructus and Rhei Radix et Rhizoma.

关 键 词：枳壳 大黄 配伍 黄酮类成分 蒽醌类成分 

分 类 号：R284.1[医药卫生—中药学]