艾滋病合并马尔尼菲青霉菌感染的实验室检测特征  

Clinical laboratory examination of AIDS complicated with disseminated peninclilum marnefei infection

作　　者：黄慧谦[1] 詹能勇[1] 吴驰[1] 吕宁[1] 侯志平[1] 陆加刚[1] 罗莎莎[1] 单万水[1] 

机构地区：[1]深圳市第三人民医院检验科,广东深圳510820

出　　处：《中国现代医学杂志》2012年第22期39-42,共4页China Journal of Modern Medicine

基　　金：深圳市卫生局科技项目专项经费资助(No:200703008)

摘　　要：目的探讨艾滋病合并播散性马尔尼菲青霉菌感染的临床实验室特征。方法回顾56例艾滋病合并播散性马尔尼菲青霉菌感染者的实验室资料并对其进行统计学分析。结果艾滋病合并播散性马尔尼菲青霉菌感染者,外周血在沙氏琼脂培养基中马尔尼菲青霉呈酵母相(37℃)或菌丝相(25℃);外周血细胞计数三系均降低;外周血T淋巴细胞亚群计数CD4细胞显著减少(<50个/μL);T总淋巴细胞、辅助性T淋巴细胞、杀伤性T淋巴细胞均异常;肝功能受损患者(占63%),血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)升高,血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)延长。结论艾滋病中晚期患者如出现相关的临床症状及实验室特征,提示马尔尼菲青霉菌感染,以便早诊断、早治疗。【Objective】To explore the clinical laboratory characteristics of AIDS complicated with disseminated Peninclilum Marnefei infection.【Methods】The laboratory data of 56 patients with AIDS complicated with disseminated peninclilum marnefei infection were retrospectively analyzed.【Results】Fungus cultured：yeast like cells were found in the culture at 37℃ in tissues.When cultured at 25℃,the fungus was mycelia like and produced a characteristic red pigment diffusing into the medium.Blood corpuscle count were all reduced;CD4 cell count was reduced significantly（50 /UL）,hepatic enzymes coagulated dysfunction was high.【Conclusion】If the advanced patients with AIDS have related clinical symptoms and laboratory characteristics,they can be considered as peninclilum marnefei infection in order to early diagnosis and treatment.

关 键 词：艾滋病 马尔尼菲青霉菌 合并感染 

分 类 号：R593.32[医药卫生—内科学]