功能化离子液体为载体液相合成RGD三肽  

Solution phase synthesis of RGD tripeptide using functionalized ionic liquid as support

作　　者：徐中义[1] 陈卓[1] 李梅[1] 董娴[1] 

机构地区：[1]贵州师范大学化学与材料科学学院,贵州贵阳550001

出　　处：《化学研究与应用》2012年第10期1613-1616,共4页Chemical Research and Application

基　　金：国家自然科学基金项目(20862004)资助;贵州省科学技术基金项目(黔科合J字[2009]2027号)资助;贵州省科学技术基金项目(黔科合J字[2007]2022号)资助

摘　　要：以甲基咪唑、氯乙醇和四氟硼酸钠为原料制备了含羟基的功能化离子液体l-(2-羟乙基)-3-甲基咪唑四氟硼酸盐([2-hydemim][BF4]),并以其为液相载体,精氨酸、甘氨酸和天冬氨酸为原料,探讨了液相支载合成了精氨酰-甘氨酰-天冬氨酸三肽(RGD)的新方法,最后在温和的条件下用氢氧化钠进行切割反应,得到了产率和纯度较高的RGD三肽,目标化合物不需要进一步的色谱纯化,产率为84%,纯度为98%。Hydroxyl functionalized ionic liquid 1 -（ 2-hydroxyethyl ） -3-methylimidazolium tetrafluoroborate （ [ 2-hydemim ] [ BF4 ] ） was prepared via methylimidazolium, chlorohydrin and sodium tetrafluoroborate as materials. Taking arginyl, glycyl and aspartic acid as raw materials, solution phase synthesis of Arg-Gly-Asp tripeptide（RGD） using hydroxyl functionalized ionic liquid as support was developed. The target compound was obtained in good yields and high purities without chromatographic purification after mild cleav- age with sodium hydroxide in tetrahydrofuran at room temperature. The purity of the target compound was 98% and the yield was 84%.

关 键 词：功能化离子液体 液相有机合成 载体 组合化学 精氨酰-甘氨酰-天冬氨酸 

分 类 号：O629.72[理学—有机化学]