2型糖尿病患者持续皮下输注胰岛素达标剂量的相关因素研究  

Multiple Factors of Standard Dose of Insulin in the Treatment of Type 2 Diabetes with Continuous Subcutaneous Injection

作　　者：罗蕴之[1] 

机构地区：[1]新疆维吾尔自治区人民医院内分泌科,乌鲁木齐830000

出　　处：《中国药房》2012年第40期3784-3785,共2页China Pharmacy

摘　　要：目的:探讨持续皮下输注胰岛素治疗2型糖尿病胰岛素达标剂量的相关因素,为临床估算胰岛素总剂量提供参考。方法:收集在我院治疗的78例应用皮下胰岛素泵治疗的2型糖尿病患者的胰岛素达标剂量数据,测定各临床指标,分析患者胰岛素达标剂量与糖化血红蛋白、空腹血糖、体重指数及体重的相关性。结果:患者血糖控制达标时的胰岛素总剂量与空腹血糖、体重指数呈正相关(P<0.05),其中空腹血糖与胰岛素达标剂量相关性最好,可用公式表示:胰岛素总量(u)=3.62×治疗前空腹血糖(mmol·L-1)。结论:2型糖尿病患者血糖控制达标时的胰岛素总剂量与空腹血糖最相关,因此临床可根据患者空腹血糖估算胰岛素达标剂量。OBJECTIVE： To investigate the relative factors of standard dose of insulin in the treatment of type 2 diabetes with continuous subcutaneous injection, and to provide reference for the clinical estimation of insulin total dose. METHODS： The dose of insulin in 78 patients with subcutaneous insulin pump was collected, and clinical indicators were measured. The relationship of total dose of insulin with glycated hemoglobin, fasting glucose, body mass index and weight was analyzed. RESULTS： The total dose of insulin was positively correlated with fasting glucose and body mass index when the blood glucose of patients was in line with the standard （P〈0.05）, especially between fasting glucose and standard dose of insulin, expressed by equation： total dose of insulin （u）= 3.62 × fasting blood glucose before treatment （mmoL·L^-1）. CONCLUSION： When blood glucose of patients with type 2 diabetes has been kept at standard level, total dose of insulin is closely correlated with fasting glucose. We can estimate the total dose of insulin according to fasting blood glucose of patient.

关 键 词：2型糖尿病 胰岛素达标剂量 相关性 因素 

分 类 号：R5[医药卫生—内科学]