大同市妊娠期女性HPV感染调查及基因型分析  

Prevalence and types distribution of human papillomavirus infection for pregnant women in Datong,China

作　　者：郭俊成[1] 车秀英[2] 刘润花[3] 赵富玺[1] 

机构地区：[1]山西大同大学医学院免疫学研究所,山西大同037009 [2]大同市第五人民医院妇产科 [3]山西大同大学医学院妇科实验室

出　　处：《现代预防医学》2012年第19期4962-4963,4965,共3页Modern Preventive Medicine

基　　金：山西省青年科技研究基金 (2007021051)

摘　　要：目的调查大同市妊娠期女性人乳头瘤病毒(HPV)感染及亚型分布情况。方法采用PCR以及线形杂交法(LA)对177例妊娠期女性宫颈脱落细胞标本进行HPV检测和基因分型。结果大同市妊娠期女性HPV感染率为38.42%,妊娠早期感染率最高(57.35%,P﹤0.005),且以多型别为主(73.92%)。HPV-16、HPV-58、HPV-18、HPV-11以及HPV-6的感染率最高,分别为15.82%,4.52%,3.95%,3.95%和3.39%。结论大同市妊娠期女性HPV的感染较为普遍,HPV亚型分布具有明显的地域特征,妊娠早期女性为易感人群。OBJECTIVE To survey the prevalence and type distribution of human papillomavirus（HPV） infection of pregnant women in Datong.Materials and METHODS A total of 177 cervical specimens from pregnant women were collected for HPV detection and genotype by PCR-LA assay.RESULTS The overall HPV prevalence was 38.42%,and multiple HPV genotypes wrer observed more frequently in the first trimester of pregnancy,and the pattern of infection changed significantly depending on pregnancy stages（P﹤0.005）.The overall prevalence of HPV types were HPV-16,HPV-58,HPV-18,HPV-11 and HPV-6 in pregnant women.CONCLUSION This study demonstrated the geographic characteristics of oncogenic HPV distribution in Datong,China.To design an effective HPV screening program,more attention should be focused on pregnant women.

关 键 词：人乳头瘤病毒(HPV) 妊娠期 基因型 

分 类 号：R373.9[医药卫生—病原生物学]