过敏性紫癜患儿血清LXA4、sVCAM-1与TNF-α表达的意义  

Significance of expression on serum lipoxin a4,soluble vascular cell adhesion molecule-1 and tumor necrosis factor-α in children with henochschoenlein purpura

作　　者：孙兴珍[1] 朱从龙[1] 舒思静[1] 

机构地区：[1]南京医科大学附属淮安第一医院儿科,淮安223300

出　　处：《现代预防医学》2012年第19期4997-4998,5003,共3页Modern Preventive Medicine

摘　　要：目的探讨血清脂氧素A4(LXA4)、可溶性血管细胞黏附分子-1(sVCAM-1)、肿瘤坏死因子-α(TNF-α)在过敏性紫癜(HSP)患儿表达的意义。方法采用双抗体夹心酶联免疫吸附法分别测定56例HSP患儿及25例健康儿童(对照组)血清LXA4、sVCAM-1和TNF-α含量,分别比较其急性期和恢复早期上述因子表达水平。结果 HSP患儿急性期和恢复早期血清LXA4、sVCAM-1、TNF-α水平均显著高于对照组;HSP患儿急性期血清sVCAM-1和TNF-α水平均显著高于恢复早期;而血清LXA4水平明显低于恢复早期(P﹤0.01)。结论 sVCAM-1、TNF-α可能参与HSP发病过程,而LXA4可能有抗炎作用。OBJECTIVE To investigate the levels of serum lipoxin A4（LXA4）,soluble vascular cell adhesion molecule-1（sVCAM-1） and tumor necrosis factor-α（TNF-α） in children with Henoch-Schoenlein purpura（HSP） and its clinical significance.METHODS The serum levels of LXA4,sVCAM-1 and TNF-α were measured by enzyme-linked immunosorbent assay（ELISA） in 56 children with HSP and in 25 healthy subjects（control group） respectively,and the change that in acute stage and recovery stage was analyzed.RESULTS The serum levels of LXA4,sVCAM-1 and TNF-αof HSP children in acute stage and early recovery stage were significantly higher than those in control group.Serum levels of sVCAM-1 and TNF-α in acute phase of HSP children were significantly higher than those in early recovery phase,while the serum level of LXA4 in acute phase of HSP children was significantly lower than that in early recovery phase.CONCLUSION sVCAM-1 and TNF-α may be involved in the pathogenesis of HSP,and LXA4 may have anti-inflammatory effects.

关 键 词：过敏性紫癜 脂氧素A4 可溶性血管细胞黏附分子-1 肿瘤坏死因子-Α 

分 类 号：R554.6[医药卫生—血液循环系统疾病]