中药复方"生发灵"药效学初步研究  

Preliminary Pharmacodynamic Study of Chinese Herbal Compounds "Sheng Fa Ling"

作　　者：周正平[1] 吴斌 李季 张奉国[1] 

机构地区：[1]中国药科大学,江苏南京210009 [2]南京同仁医院,江苏南京211100

出　　处：《现代生物医学进展》2012年第27期5376-5379,5280,共5页Progress in Modern Biomedicine

摘　　要：目的:研究中药复方"生发灵215"的两种提取方法和生发作用。方法:参考该中药复方的传统临床应用,考察了该复方的两种提取方法:一是用油提取直接涂抹的传统方法,一是用醇提法并制成软膏剂。然后用两种提取物对试验兔进行皮肤刺激性实验和促毛发生长作用的初步探讨。结果:软膏剂在外观、手感以及使用舒适度方面均大大优于传统的油提取物。皮肤刺激实验表明油提物对完整皮肤和破损皮肤均有刺激性,而通过醇提物制备的软膏制剂作用温和,没有发现明显的刺激性。毛发生长实验表明,醇提物制备的软膏制剂在促毛发生长效果方面和油提物没有明显差异。结论:醇提物制成的软膏剂具有良好的临床应用价值。Objective： To investigate two extraction methods and the effect or hair tonic about traditional Chinese medicine ＂Sheng Fa Ling 215＂. Methods： Reference to the traditional application of the compound, two extraction methods was investigated. One was the traditional methods that directly applied using oil extract; another was the alcohol extract which made of ointment. The skin irritation and the hair tonic with the experiment＇s rabbits by two extraction methods was also preliminary studied. Results： Ointment was much better than traditional oil extracts in appearance, feel and comfort. Skin irritation test showed that the oil extract on the intact skin and broken skin had irritation, Ointment prepared by the alcohol extract was mild and no obvious irritation. Hair growth experiments showed that there was no significant difference between Ointment and oil extract in promoting hair growth effects. Conclusion： Ointment has good application value in clinic.

关 键 词：中药 生发 制剂 药效 

分 类 号：R285[医药卫生—中药学]