肾小管标志物在慢性肾小球肾炎治疗前后变化的意义  

Significance of change of renal tubule markers before and after treatment in chronic glomerulonephritis

作　　者：解冰[1] 江利萍[1] 

机构地区：[1]江苏省镇江市中西医结合肾脏病研究所,212028

出　　处：《检验医学与临床》2012年第19期2436-2437,2439,共3页Laboratory Medicine and Clinic

摘　　要：目的通过测定肾小管标志物判断慢性肾小球肾炎(GN)患者的肾小管受损程度,以期探讨在不同疗效的患者治疗前后的意义。方法应用放射免疫法测定白细胞介素-6(IL-6);免疫浊度法测定α1-微球蛋白(α1-MG)、β2-微球蛋白(β2-MG);ELISA法测定纤维蛋白原降解产物(FDP);速率法测定N-乙酰β-D氨基葡萄糖苷酶(NAG);物理法测定纯水清除率(CH2O)。结果在完全缓解的病例中α1-MG、β2-MG、FDP等多种肾小管标志物经治疗后均下降(P<0.05),而CH2O没有明显改变(P>0.05);在无效组中IL-6、α1-MG、FDP下降不明显(P>0.05)。结论通过监测多种肾小管标志物可以用于诊断和监测以及判断GN患者的疗效,对治疗起指导作用。Objective To evaluate the damage degree of renal tubule in the patients with chronic glomerulonephritis（GN） by detecting renal tubule markers and to investigate their significance before and after treatment in the patients with different therapeutic effects.Methods Interleukin-6（IL-6） was detected by RIA,α1-microglobulin（α1-MG） and β2-microglobulin（β2-MG） by the immune turbidity method,the fibrinogen degradation product（FDP） by ELISA,N-acetyl-β-D-glucosaminidase（NAG） by the rate method and CH2O by the physical method respectively.Results α1-MG,β2-MG,FDP were significantly decreased after therapy in the cases of complete remission（P0.05）,but CH2O had no obvious change（P0.05）.The decrease of IL-6,ET-1,α1-MG and FDP were not significant in the invalid group（P0.05）.Conclusion The determination of several renal tubule markers can diagnose,monitor and judge the therapeutic effects of GN and plays a guidance role in therapy.

关 键 词：慢性肾炎 Α1-微球蛋白 Β2-微球蛋白 纯水清除率 白细胞介素-6 

分 类 号：R277.523.1[医药卫生—中医学]