氯胺酮对兔定量药物脑电图δ频段的影响  

Effects of ketamine on the δ-band power percentage of quantitative pharmaco-EEG in rabbits

作　　者：蔡慧明[1] 韩平平[1] 王虹[1] 王琦[2] 戴体俊[3] 

机构地区：[1]徐州医学院药学院,江苏徐州221002 [2]徐州医学院附属二院,江苏徐州221002 [3]徐州医学院麻醉药理教研室,江苏徐州221002

出　　处：《华西药学杂志》2012年第5期525-527,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:30872432;30471657)

摘　　要：目的探讨氯胺酮对兔定量药物脑电图(QPEEG)δ频段功率百分比的影响。方法将24只成年白色家兔随机均分为NS组、KET4组、KET8组及KET16组,分别于耳缘静脉注射NS及4、8、16 mg.kg-1的氯胺酮,观察并比较各组家兔给药前后QPEEGδ频段的功率变化。结果兔静脉注射氯胺酮4、8、16 mg.kg-1后,各脑区的δ频段功率百分比在0.5～5 min内均较给药前明显增加,1～2 min达高峰。在给药后0.5～5 min内随氯胺酮剂量的增大,δ频段功率百分比的增加越明显。结论氯胺酮可剂量依赖性地增加兔QPEEGδ频段的功率百分比,提示QPEEGδ频段功率百分比有可能成为监测氯胺酮麻醉深度的指标。OBJECTIVE To investigate the effects of ketamine on the δ-band power percentage of quantitative pharmaco-EEG（QPEEG） in rabbits.METHODS 24 adult rabbits were randomly divided into 4 groups and were intravenously injected with 4,8,16 mg·kg-1 of ketamine and nomal saline respectively.The power spectral analysis was conducted to check the changes of δ-band power percentage of QPEEG in each group before and after drug infusions.RESULTS After the rabbit was injected,the δ-band power percentage of each brain region significantly increased from 0.5 min to 5 min（P0.05,P0.01） and reached its peak between 1 min and 2 min.Moreover,a positive correlation between δ-band power percentage and the doses of ketamine was detected from 0.5 min to 5 min.CONCLUSION Ketamine can increase the δ-band power percentage of QPEEG in a dose-dependent manner,which suggests that δ-band power percentage of QPEEG may be a desired index of the depth of anesthesia monitoring.

关 键 词：氯胺酮 定量药物脑电图 麻醉深度 Δ频段 功率百分比 

分 类 号：R96[医药卫生—药理学]