益母草碱对实验性高脂血症大鼠的降脂作用  

Effect of leonurine on blood lipid in experimental hyperlipidemia rats

作　　者：钱海兵[1] 徐玉平[1] 罗魁[1] 

机构地区：[1]贵阳中医学院,贵州贵阳550002

出　　处：《华西药学杂志》2012年第5期528-530,共3页West China Journal of Pharmaceutical Sciences

基　　金：贵州省国际科技合作项目(黔科合外G字[2010]7012)

摘　　要：目的考察益母草碱对高脂饲料所诱导的高脂血症大鼠的血脂、血液流变学及微循环的影响。方法建立大鼠高脂血症模型,益母草碱按高、中、低剂量(10、5、2.5 mg.kg-1)ip给药4周,观察益母草碱对高脂血症大鼠的血脂、血液流变学以及肠系膜微循环的影响。结果益母草碱10、5 mg.kg-1可纠正高脂血症大鼠的血脂代谢紊乱,降低血清总胆固醇、甘油三酯和低密度脂蛋白胆固醇的含量,降低血液流变学的各项异常指标,扩张微血管,改善微循环。结论益母草碱具有一定的降脂及改善微循环、血流变的作用。OBJECTIVE To study the effects of leonurine on blood lipid,hemorheology and auricle microcirculation in experimental hyperlipidemia rats.METHODS The rats were fed with the high-fat foods for 8 weeks to establish hyperlipidemia rats model,and then they were divided into Leonurine high-dose（10 mg·kg-1）,middle-dose（5 mg·kg-1）,low-dose（2.5 mg·kg-1）,model group and Xuezhikang capsule group,and administered for 4 weeks.Then the concentration of serum triglyceride（TG）,cholesterol（TC）,high-density lipoprotein（HDL-C）,low-density lipoprotein（LDL-C）,abnormal hemorheological parameters and auricle microcirculation were assayed.RESULTS The serum levels of TG,TC and LDL-C in rats treated with Leonurine（10,5 mg·kg-1） were lowered significantly（P0.05）.The abnormal hemorheological parameters were reduced and the auricle microcirculation was improved.CONCLUSION Leonurine can reduce the serum lipids and thermodynamics index while improve auricle microcirculation.

关 键 词：益母草碱 高脂血症 血脂 血流变 微循环 

分 类 号：R96[医药卫生—药理学]