温度及pH对替莫唑胺溶液稳定性的影响  

Influence of pH and temperature on the stability of Temozolomide solution

作　　者：郑蓉[1] 蒋德锡[1] 廖心丹[1] 张丹[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2012年第5期550-551,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的考察pH、温度对替莫唑胺溶液稳定性的影响。方法采用紫外分光光度法,于不同时间测定不同温度及pH条件下溶液中替莫唑胺的含量,得其降解曲线。结果替莫唑胺溶液在低温和酸性条件下稳定性良好;在碱或高温条件下不稳定,降解符合一级动力学规律。结论碱、高温对替莫唑胺溶液的稳定性有较大影响。OBJECTIVE To investigate the influence of pH and temperature on the stability of Temozolomide solution.METHODS The concentration of Temozolomide in different pH and temperature at different time points were determined by ultraviolet spectrophotometry,and the remaining propotion versus time curves was plotted.RESULTS Low temperature and acid environment were helpful for the stability of Temozolomide solution,while basic condition or high temperature could accelerate its degradation,which fitted a first-order process.CONCLUSION Temozolomide solution is unstable under basic condition and high temperature.

关 键 词：稳定性 替莫唑胺 紫外分光光度法 PH 温度 

分 类 号：R917[医药卫生—药物分析学]