基于中医传承辅助系统的治疗慢性心力衰竭方剂组方规律分析  

Analysis on Principles of Prescriptions for Chronic Heart Failure by Using Traditional Chinese Medicine Inheritance System

作　　者：赵鑫[1] 崔向宁[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中国实验方剂学杂志》2012年第19期8-11,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(30873208)

摘　　要：目的:基于中医传承辅助系统软件,应用数据挖掘技术研究临床治疗慢性心力衰竭方剂的用药规律。方法:收集北京地区两所三甲医院中西医结合心内科治疗慢性心力衰竭病历272份,采用频次统计法、改进的互信息法、复杂系统熵聚类、无监督的熵层次聚类等无监督数据挖掘方法,对其处方进行数据挖掘研究。结果:临床治疗慢性心力衰竭使用频率较高的药物有78味,使用频次均在12次以上;常用药对32个,其关联系数均在0.02以上;演化得到核心组合26个,新处方13个。结论:复杂系统熵聚类、无监督的熵层次聚类等无监督数据挖掘技术分析治疗慢性心衰方剂的用药规律具有一定的科学性;中医传承辅助系统实现对方剂录入、管理和分析,对于研究中药组方规律和发现新处方有重要意义。Objective：To analyze the principles of prescriptions for chronic heart failure by using deta mining technology based on Traditional Chinese Medicine Inheritance System.Method：The retrospective analysis of 272 patients with chronic heart failure treated by traditional Chinese medicine in two Three-A hospitals of Beijing by using the data mining methods,such as revised mutual information,complex system entropy cluster and unsupervised hierarchical clustering,etc.Result： Seventy-eight kinds of herbs were used frequently in clinical and 32 drug collocation correlative coefficients are more than 0.02;26 core combinations and 13 new prescriptions were mined from the database.Conclusion：Traditional Chinese Medicine Inheritance System is a helpful tool on entrying,administration and analyzing of the prescriptions and it has importance for creating new prescriptions.

关 键 词：慢性心力衰竭 数据挖掘技术 中医传承辅助系统 组方规律 

分 类 号：R287.6[医药卫生—中药学]