多指标综合评分法优选当归芍药散提取工艺  

Optimization of Extraction Technology for Danggui Shaoyao Powder by Multiple-index Comprehensive Scoring Method

作　　者：周瑜[1] 陶春蕾[1] 许钒[1] 宋欣[1] 王成业[1] 

机构地区：[1]安徽省高等学校省级现代中药重点实验室安徽中医学院药学院,合肥230038

出　　处：《中国实验方剂学杂志》2012年第19期20-23,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金面上项目(81173368);安徽省高校自然科学研究重点项目(KJ2010A213)

摘　　要：目的:优选当归芍药散的提取工艺。方法:以芍药内酯苷、芍药苷、阿魏酸、23-乙酰泽泻醇B为评定指标,用多指标综合评分法进行数据处理,选取提取时间、提取次数、乙醇体积分数及乙醇用量为考察因素,采用正交试验优化提取条件。结果:最佳提取工艺为加8倍量75%乙醇回流提取2次,每次1.5 h。结论:该提取工艺稳定、合理,有效成分提取率高。Objective：To optimize extraction conditions of Danggui Shaoyao powder.Method：With the content of albiflorin,paeoniflorin,ferulic acid and 23-acetate alisol B as indexes,test data was handled by multiple-index comprehensive scoring method,orthogonal test was adopted in optimizing extraction technology with extraction time,extraction times,the concentration of ethanol and ethanol volume as factors.Result： Optimized extraction technology was：extracted 2 times with 8 times the amount of 75% ethanol,1.5 h per time.Conclusion：This optimized extraction technology was rational and stable with high yield of active components.

关 键 词：当归芍药散 芍药内酯苷 芍药苷 阿魏酸 23-乙酰泽泻醇B 正交试验 综合评分法 

分 类 号：R283.6[医药卫生—中药学]