黄杨生物碱的研究新进展  

Progress on Study of Buxus alkaloids

作　　者：吕霞[1] 于盱[2] 郭青[3] 马玉琴 

机构地区：[1]江苏联合职业技术学院连云港中医药分院,江苏连云港222007 [2]江苏省中国科学院植物研究所,南京210014 [3]江苏省食品药品检验所,南京210008 [4]连云港环境监测中心站,江苏连云港222001

出　　处：《中国实验方剂学杂志》2012年第19期315-321,共7页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：对黄杨属植物的主要活性成分黄杨生物碱的结构和生物活性的研究进行了文献整理,为黄杨的深度开发提供参考。主要对1992-2011年国内外有关黄杨生物碱的结构和生物活性研究方面的文献进行了归纳、分析和总结。1992年至今,已经从8种黄杨属植物中分离出了100余种新黄杨生物碱,而且发现一些生物碱具有很好的生物活性,如抗HIV病毒,抗菌,肿瘤以及抑制乙酰胆碱酯酶(AChE)、丁酰胆碱酯酶(BuChE)和谷胱苷肽转移酶(GST)等等。全世界黄杨属植物有70多种,目前只对少数进行了研究,特别是黄杨生物碱的生物活性研究还处于起始阶段。因此,在药理学指导下的化学成分研究成为今后研究的重要方向,这样不仅可为阐明黄杨生物碱类成分的生物效应和药用价值提供依据,并为加快黄杨属植物的开发和利用提供依据。To summarize the research progress of chemical structures and biological activities of Buxus alkaloids,which are rich in plants of genus Buxus and provide useful references for the further research.Literature about Buxus alkaloids between 1992 to 2011 in plenty of journals and books were referred to,and the progress of chemical structures and biological activities were summarized.Since 1992,more than 100 alkaloids have been isolated from 8 kinds of plants of genus Buxus.Many researches suggested some of Buxus alkaloids exhibit biological activities including anti-HIV activity,antibacterial,antimycobacterial,antimalarial,antitumor,and inhibitory activities against acetylcholinesterase（AChE）,butyrylcholinesterase（BuChE） and glutathione S-transferase（GST）.There are more than 70 kinds of plants of genus Buxus all over the world,but only a minority of them has been studied at present.And little research about biological activities of Buxus alkaloids have been reported.In order to develop the medicinal application of the genus of plants,chemical constituents together with pharmacological activities and mechanism should be conducted.Meanwhile,the biological effects and the medical value compounds will be clarified.

关 键 词：黄杨属 黄杨生物碱 化学成分 生物活性 

分 类 号：R284.1[医药卫生—中药学]