雷公藤单体抑制神经胶质瘤的研究进展  

Research Progress in Researches on Inhibition of Glioma by Monomers Isolated from Tripterygium Wilfordii

作　　者：李建斌[1] 祝新根[1] 程祖珏[1] 

机构地区：[1]南昌大学第二附属医院神经外科,南昌330006

出　　处：《中国实验方剂学杂志》2012年第19期325-328,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：江西省教育厅项目(EF130)

摘　　要：雷公藤单体是从传统中草药雷公藤中分离出的化学单体成分,主要包括二萜、三萜、倍半萜、生物碱等,具有免疫抑制、抗炎、抗肿瘤等活性。近年来的文献报道雷公藤单体中雷公藤甲素和雷公藤红素以剂量-效应方式抑制颅内恶性肿瘤神经胶质瘤生长。其作用与调控抗凋亡蛋白Bcl-2,促凋亡蛋白Bax、核因子NF-κB的表达及下调Ras/Akt和Ras/ERK信号转导通道诱导肿瘤细胞凋亡;降低RNA聚合酶转录活性,抑制肿瘤细胞的增殖分化;抑制血管内皮细胞(EC)的血管内皮生长因子(VEGF)受体降低EC的增殖、迁移及小管的形成能力抑制肿瘤血管生成等机制相关。深入研究雷公藤单体的生物学效应及其分子机制将有助于阐明其药理机制。寻找高效低毒的单体将是今后研究的重点。Monomers isolated from Tripterygium Wilfordii are mainly chemical compositions including two terpene,three terpene,half terpene,alkaloids,etc.The monomers show effectiveness in suppression of autoimmune diseases as well as anti-inflammatory and antitumor activity.Recent reports in the literatures show that triptolide and celastrol isolated from Tripterygium Wilfordii could inhibit glioma growth by ways of tumor cell apoptosiss,inhibition to tumor cell proliferation and differentiation and refrainning tumor angiogenesis in a dose-effect manner.The mechanism involves regulating expression of Bcl-2,Bax,NF-kappa B and down-regulating Ras/Akt and Ras/ERK signal pathways.They could reduce the RNA polymerase transcription and lower the vascular endothelial cells（EC） proliferation,transference,and the ability for forming small tube by inhibiting vascular endothelial growth factor（VEGF） receptor.The studies on bio-responses and the related molecular mechanism of the monomers will certainly help to illustrate the pharmacologic mechanism of actions.The future emphases will be the development of new monomers with high efficacy and low toxicity.

关 键 词：神经胶质瘤 雷公藤 雷公藤甲素 雷公藤红素 

分 类 号：R285.5[医药卫生—中药学]