溃愈散对溃疡性结肠炎患者血清白细胞介素6、白细胞介素8的影响  

Study on influences of Kuiyu dection on contents of IL-6 and IL-8 in patients with ulcerative colitis

作　　者：张立泽[1] 乔翠霞[1] 薛辉 刘鹏林[1] 赵刚[1] 

机构地区：[1]青岛大学医学院附属医院肛肠科,266003 [2]青岛市海慈医疗集团中医妇科,266000

出　　处：《国际中医中药杂志》2012年第10期882-885,共4页International Journal of Traditional Chinese Medicine

基　　金：青岛市公共领域科技支撑计划课题（项目编号：09-1-1-45-nsh）

摘　　要：目的探讨溃愈散治疗溃疡性结肠炎（ulcerativecolitis，UC）的临床疗效及其作用机制。方法将120例溃疡性结肠炎患者按照完全随机方法分为两组各60例，治疗组采用溃愈散保留灌肠治疗，1次／d；对照组口服柳氮磺胺吡啶片，1g／次，3次／d，两组患者均治疗15d为1个疗程，间隔后7d进行下个疗程，3个疗程后比较两组患者的临床综合疗效、主要症状、结肠镜镜检积分改善情况，以及治疗前后患者血清白细胞介素6（IL-6）、白细胞介素8（IL-8）的水平变化，治疗后对两组完全缓解及有效病例随防6个月，观察其复发率。结果治疗组总有效率为93．33％，优于对照组78．33％（x^2=9．027，P〈0．05）；治疗后治疗组较对照组在腹泻、脓血便的改善上更为明显（矿值分别为5．630、5．972，P〈0．05），能明显降低UC患者血清IL-6、IL-8的水平（x^2=8-314，P〈0．01）；结肠镜镜检积分显示两组治疗后充血、糜烂、溃疡均有明显改善，治疗组优于对照组（x^2=8．322，P〈0．05）；随访6个月，治疗组复发率低于对照组，差异有统计学意义（x^2=5．857，P〈0．05）。结论溃愈散通过下调IL-6、IL-8水平治疗溃疡性结肠炎，缓解率高、安全性好。Objective To observe the effect of Kuiyu dection on ulcerative colitis and to explore its mechanism. Methods 120 patients with ulcerative colitis were randomly divided into a treatment group and a control group, 60 cases in each group. The treatment group was treated with Kuiyu dection retention enema, 1 time a day, 15 days for a course of treatment; and the control group was treated with SASP orally, 2 g every time,3 times a day, and 15 days for a course of treatment. All patients with a course of treatment for the next 7 days after the rest period of treatment, evaluated after 3 courses. Comprehensive clinical efficacy, the main symptoms, score of integral electronic colonoscopy examination, and the changes of IL-6, IL 8 levels were observed in both groups after treatment with complete remission and six months followed-up, besides, the recurrence rate was also observed. Results The total effective rate was 93.33% in the treatment group, better than the control group 78.33% （x^2=9.027, P〈0.05） ; the treatment group also showed better results in diarrhea, pus and blood improvement than the control group （x^2= 5.630, x^2= 5.972, P〈0.05）, the treatment group could significantly reduce UC Serum IL-6, IL-8 level （x^2=8.314, P〈0.01）; electronic colonoscopy examination points, hyperemia, erosions, ulcers in both groups were significantly improved, but the treatment group was significantly better than the control group （x^2=8.322, P〈0.05） ; 6 months followed-up and the recurrence rate in treatment group were better than control group, and the difference was statistically significant （x^2=5.857, P〈 0.05）. Conclusion Through decreasing the IL-6, IL 8 levels, Kuiyu dection can treat ulcerative colitis, with significant effect, non-toxic side effects, inexpensive, and easy for use.

关 键 词：溃愈散:溃疡性结肠炎 白细胞介素6 白细胞介素8 

分 类 号：R285[医药卫生—中药学]