大柴胡汤灌肠对急性胰腺炎患者血浆炎性因子的影响  

Research on the effect of Dachaihu decoction on plasma inflammatory cytokines of acute pancreatitis patient

作　　者：林永泉[1] 荣丽华[1] 

机构地区：[1]山东省潍坊市益都中心医院急诊科,青州262500

出　　处：《国际中医中药杂志》2012年第10期886-887,共2页International Journal of Traditional Chinese Medicine

摘　　要：目的观察大柴胡汤灌肠对急性胰腺炎患者血浆炎性因子的影响。方法收集2009年1月至2011年12月潍坊市益都中心医院急诊科186例急性胰腺炎患者，按随机数字表法分为中药组94例和对照组92例，对照组给予西医常规治疗，中药组在西医常规治疗的基础上给予大柴胡汤灌肠，2次／d连续7d。分别于第2、5、7天检测两组患者的肿瘤坏死因子α（TNF-α）、白细胞介素1β（IL-1β）、白细胞介素6（IL-6）水平。结果治疗第2、5、7天中药组患者的TNF-α为[（42．18±20．57）mg／L、（22．06±10．73）mg／L、（9．88±4．62）mg／L]，IL-1β为[（0．28±0．11）μg/L、（0．19±0．02）μg/L、（0．18±0．06）μg/L，IL-6[（87．90±49．41）ng／L、（16．59±10．24）ng／L、（14．96±11．42）ng／L]，均低于对照组治疗第2、5、7天[TNF-α分别为（53．18±20．53）mg／L、（43．78±11．08）mg／L、（19．69±11．53）mg／L；IL-1β分别为（0.31±0．04）μg/L、（0．25±0．12）μg/L、（0．22±0．07）μg/L；IL-6分另0为（96．43±31．48）ng／L、（51．63±37．16）ng／L、（44．36±27．54）ng／L，P均〈0．05]的水平。结论大柴胡汤灌肠有助于降低急性胰腺炎患者血浆炎性因子水平。Objective To observe effect of Dachaihu decoction on plasma inflammatory cytokines of acute pancreatitis patients. Methods 186 cases of acute pancreatitis were randomly recruited into TCM group and control group. The control group was given routine treatment. On the basis of the control group, the TCM group was given Dachaihu decoction for enema additionally, twice daily, 7 days. Then plasma inflammatory cytokines level was tested in both groups. Results TCM group had lower levels ofTNF-α [ （42.18 ±20.57）mg/L （22.06±10.73）mg/L, （9.88±4.62）mg/L], IL-1β[（0.28±0.11）μg/L, （0.19 ± 0.02） μg/L, （0.18±0.06）ktg/L], and IL-6[（87.90±49.41）ng/L, （16.59±10.24） ng/L, （14.96±11.42） ng/L] at 2/5/7 days than the control group. There were statistical difference （P〈0.05）. Conclusion Enema with Dachaihu decoction was effective on reducing plasma inflammatory cytokines level. It was probably the key to cure acute pancreatitis.

关 键 词：大柴胡汤 急性胰腺炎 炎性因子 

分 类 号：R259[医药卫生—中西医结合]