动态流变学评价双黄连即型凝胶的胶凝性质  

Evaluation on gelling properties of Shuanghuanglian in situ gel by dynamic rheology

作　　者：陈两绵[1] 王锦玉[1] 仝燕[1] 郑炳林 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]奥地利安东帕有限公司北京分公司,北京100020

出　　处：《中国中药杂志》2012年第19期2884-2888,共5页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2009ZX09301-005)

摘　　要：目的:应用动态流变实验测定双黄连即型凝胶(SHL-gel)的流变性质,评价其胶凝性质,预测其在体胶凝行为。方法:采用剪切速率、频率扫描测定SHL-gel在不同温度下的流变参数,采用程序升温/降温、快速升温/恒温测试表征其相转变过程。结果:SHL-gel在低温或室温条件下,相角δ接近90°,黏性特征占主导,为牛顿流体;在体温条件下,相角δ很小,弹性特征占主导,为剪切变稀的假塑性流体;相转变过程中,相角δ急剧减小,模量呈指数增涨,胶凝温度(Tg)为(35.38±0.05)℃;相变温度33.71～37.01℃;相转变时间为140 s。结论:动态流变实验能更为准确贴切的表征SHL-gel的胶凝性质,可作为产品体外评价及质量控制的依据。Objective： To determine the rheological properties of Shuanghuanglian in situ gel （SHL-gel） by using dynamic rheological experiments, in order to evaluate its gelling properties Shuanghuanglian in situ gel and predict its gelling behavior in vivo. Method： Rheological parameters were determined by scanning of shear rate and frequency at different temperatures. The phase transition process from liquid to semisolid was described by testing of process heating/cooling and acute heating/cooling. Result： SHL-gel was Newtonian fluid under the conditions of a phase angle approaching 90° at low temperature or room temperature, with its viscous characteristics dominated. It was shear-thinning pseudoplastic fluid under the conditions of a low phase angle at body temperature, with its elastic characteristics dominated. During the phase transition process, the phase angle δ was getting sharp, with exponential increase of the modulus. The gelling temperature （Tg） was at （35.38±0.05）℃, the phase transition temperature ranged from 33.71 to 37.01℃, and phase transition time was 140 s. Conclusion： The dynamic rheological experiment characterizes the gelling properties of Shuanghuanglian in situ gel so precisely that it can be used as the basis of for in vitro evaluation and quality control of products.

关 键 词：双黄连 即型凝胶 假塑性流体 动态流变学 相转变 

分 类 号：TQ461[化学工程—制药化工]