中药组分与组分生物药剂学分类系统构建  

Traditional Chinese medicine components and construction of components biopharmaceutical classification system

作　　者：刘丹[1,2] 郁丹红[1] 孙娥[1] 贾晓斌[1] 

机构地区：[1]江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京210028 [2]江苏大学药学院,江苏镇江212013

出　　处：《中国中药杂志》2012年第19期2997-3000,共4页China Journal of Chinese Materia Medica

基　　金：江苏省中医药领军人才专项(2006);江苏省中医药局中医药科技技术研究专项(LZ09061)

摘　　要：中药复方物质基础是多组分,在研究中药生物药剂学性质时,应该以组分为研究对象。针对中药多组分生物药剂学研究,该文提出科学代表中药组分综合性质的有限成分的选择思路;其次,引入"离散度"的概念,以考察组分中各代表性成分个体性质之间的差异,从而更科学全面地评价中药组分的性质;最终结合组分综合性质值及离散度,初步构建中药组分生物药剂学分类系统,为中药多组分生物药剂学性质研究提出新的思路与方法。Traditional Chinese medicine compound of material base is muhi-components. It should be divided into groups to study traditional Chinese medicine biopharmaceutical properties. To study traditional Chinese medicine muhi-compouent biopharmaceu- tieal, this paper puts forward the scientific representative Chinese medicine integrated nature of the components of the composition, choose ideas. Secondly, this paper introduces the concept of＂ ＂ discrete degree＂ to examine difference about representative nature ~ff each component. It should be more comprehensive evaluation of traditional Chinese medicine scientific nature ~ff the components. With the comprehensive property value final components and discrete degrees, setting up a part of traditional Chinese medicine biopharma- eeutical classification system, traditional Chinese medicine for the multi-composition biopharmaceutical nature study puts forward a new way and method. [Key words] components; preparation design of traditional Chinese medicine; comprehensive properties expression; discrete degree; bioavailability classification system

关 键 词：组分 中药制剂设计 综合性质表达 离散度 生物药剂学分类系统 

分 类 号：R283.6[医药卫生—中药学]