中药配伍减毒研究的新思路  

New Thought of Traditional Chinese Medicine in Detoxification by Compatibility

作　　者：李彦文[1] 李志勇[2] 刘会永[3] 谭鹏[4] 杨策[1] 赵英凯[1] 崔蒙[1] 

机构地区：[1]中国中医科学院中医药信息研究所,北京100700 [2]中央民族大学中国少数民族传统医学研究院,北京100081 [3]北京邮电大学网络与交换技术国家重点实验室,北京100876 [4]北京中医药大学中药学院,北京100102

出　　处：《中国实验方剂学杂志》2012年第20期321-324,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：科技部重大新药创制项目(2009ZX09301-005-01);国家自然科学基金青年基金项目(81001693;81102807)

摘　　要：中药配伍减毒涉及的复杂反应过程制约了对配伍减毒机制的深层次解构。阐明配伍减毒机制是解决中药毒性问题的关键。"效毒二重性"决定了有毒中药"效-毒交集"特征,交集调控可反映配伍减毒复杂过程。网络药理学的出现,为开展有毒中药毒性成分筛查、致毒机制和减毒效应等研究提供了新的手段。在回顾中药毒性研究实践的基础上,系统阐述网络药理学在中药配伍减毒研究中的应用策略,并以附子为例探讨其可行性。The complex reaction processes of traditional Chinese medicine （TCM） applications restrict the exhaustive analysis about mechanism of detoxicity by compatibility, which is the key to solve the problems of TCM toxicity. Efficacy and toxicity of drug determines the characteristics of toxic herbs with ＇Efficacy-toxicity intersection＇. With network pharmacology appeared, new methods on research about discovering toxic components in TCM, toxic mechanism and reducing toxicity will be provided. Through reviewing the practice of TCM toxicity, the article will discuss the application strategy of network pharmacology used in the research on TCM systematically and its possibility （Example： Aconiti Lateralis Radix）.

关 键 词：中药配伍 减毒 网络药理学 

分 类 号：R285[医药卫生—中药学]