胡桃楸抗肿瘤作用及其机制研究概况  

Research Review on Anti-cancer Action and Mechanism of Juglans mandshurica

作　　者：俞文婕[1] 王添敏[1] 翟延君[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600

出　　处：《中国实验方剂学杂志》2012年第20期329-332,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：高等学校博士点专项基金(新教师类)项目(20102133120007)

摘　　要：对胡桃楸的抗肿瘤机制进行整理分析。通过维普,SciFinder等数据库,查阅国内外文献。研究表明胡桃楸抗肿瘤作用的机制主要包括影响细胞周期、抑制DNA拓扑异构酶、诱导肿瘤细胞凋亡、提高免疫、损伤线粒体结构、改变细胞膜的结构和生化性质等。胡桃楸及其提取物具有的众多抗肿瘤靶向药物的特征,笔者认为其开发应用价值广阔,值得更进一步的深入研究,以期获得更高效低毒的产品。This paper is aimed to summarize the anti-cancer effects and mechanism of Juglans mandshurica. Nearly 40 documents, which were contributed by both domestic and foreign researchers, where found in the databasses sush as cqvip, sciFinder and other ones. The anti-tumor effect of the J. mandshurica can be summarized to the following 6 aspects： affecting cell cycle, inhibiting of DNA topoisomerase, inducing apoptosis of tumor ceils, improving the immune system, damaging the mitochondrial structure, changing the structure and biochemical of cell membrane. J. mandshurica, has an bright future as a anti-cancer drug and it is worthy further studies to obtain a more efficient product with lower toxicity.

关 键 词：胡桃楸 抗肿瘤机制 细胞周期 细胞凋亡 DNA拓扑异构酶 线粒体 细胞膜 

分 类 号：R285[医药卫生—中药学]