一清胶囊在肺结核合并革兰阴性菌感染中的成本一效果分析  

A cost-effectiveness analysis for treating tuberculosis patients co-infected with Gram-negative bacillus

作　　者：李月翠 胡伟跃 臧颖惠 李进 骆红霞 周晶 李成行 吴悍卫 黄金莲 

机构地区：[1]永康市第一人民医院感染性疾病科,321300

出　　处：《国际呼吸杂志》2012年第19期1463-1465,共3页International Journal of Respiration

摘　　要：目的对内毒素检测阳性的肺结核患者实施不同治疗策略，分析不同策略的成本一效果，为利用一清胶囊治疗革兰阴性菌（G）感染提供理论和经济学依据。方法120例内毒素检测阳性的肺结核患者随机分为治疗组和对照组，治疗组同时接受一清胶囊联合常规的抗菌治疗，对照组仅进行常规的抗菌治疗。分别记录患者的CRP的复常时间、体温复常时间、内毒素转阴时间以及影像的感染情况改善程度进行成本一效果分析。结果治疗组的CRP复常时间、体温复常时间和内毒素转阴时间均明显短于对照组。两组患者均未观察到空洞闭合，但治疗组47例患者的结核病灶有吸收好转（有效率78．3％）；对照组33例患者的结核病灶有吸收好转（有效率55．0％），两组比较差异有统计学意义（X^2=4．97，P〈0．05）。成本一效果分析表明对照组疗效较差且治疗成本明显偏高（P=0．013）。结论一清胶囊与常规抗菌治疗之间具有协同作用，能明显缩短病程和住院时间，两者联用成本效果更好，具有重要的经济价值。Objective To evaluate the cost-effectiveness of different strategies for treatingtuberculosis patients co-infected with Gram-negative bacillus, to provide the theoretical and economic evidences for the use of Yiqing Capsule. Methods 120 tuberculosis patients with endotoxin testing positive were randomly divided into therapy group and control group. Both groups were given anti- tuberculosi treatment and antibacterial agents, patients in treatment group were given Yiqing capsule additionally. The days until temperature normalized, levels of CRP normalized and concentration of endotoxin normalized were collected and the cost-effectiveness were conducted, improvements on images were also compared between the groups. Results The days until temperature normalized,levels of CRP normalized and concentration of endotoxin normalized in therapy group were shorter than control group （ P 〈0.05）. No empty closed after treatment in both groups, but the effective rate in treatment group was significantly higher than that in the control group （78.3 % vs. 55.0%, ;X^2 =4.97, P d0.05）. The therapy effects were poorer and the medical care expenses were higher in control goup than therapy group （ P =0. 013）. Conclusions Yiqing Capsule combined with antibacterial agents can synergisticly enhance the clinical therapeutic effect and significantly reduce the length of hospitalization, being of great value toeconomy.

关 键 词：内毒素 一清胶囊 肺结核 G感染 经济价值 

分 类 号：R521[医药卫生—内科学]