氧化应激与β2肾上腺素能受体脱敏的关系  

Relationship between oxidative stress and beta-2 adrenergic receptor desensitization

作　　者：任丽君[1] 刘华[1] 倪松石[1] 

机构地区：[1]江苏省南通大学附属医院呼吸科,226001

出　　处：《国际呼吸杂志》2012年第19期1517-1520,共4页International Journal of Respiration

基　　金：国家自然科学基金（30971306）;江苏省“六大人才高峰”项目（033）

摘　　要：氧化应激是体内活性氧和活性氮自由基产生过多，超过了机体清除速率，氧化系统和抗氧化系统失衡，导致活性氧在体内蓄积而引起的分子、细胞和机体的损伤。目前诸多研究认为氧化应激在β2肾上腺素能受体（β2-adrenergic receptor，pzAR）脱敏中起着重要作用，而β2AR脱敏会影响到β2肾上腺素能受体激动剂在支气管哮喘治疗中的效果，现就氧化应激与β2AR脱敏的关系作一综述。Oxidative stress is caused by an imbalance between the production of reactive oxygen species, reactive nitrogen species and removal, resulting in a high level of reactive oxygen species within an organism. This high level will damage molecular, cellular and organism. The currently studies have shown that oxidative stress plays an important role in β2-adrenergic receptor desensitization. However, β2-adrenergic receptor agonists have been largely restricted in the treatment of bronchial asthma because of β2-adrenergic receptor desensitization. The review is about oxidative stress and β2-adrenergic receptor.

关 键 词：氧化应激 Β2肾上腺素能受体 脱敏 

分 类 号：R562.25[医药卫生—呼吸系统]