斑蝥素及衍生物抗肿瘤机制的研究进展  

Research Progress on the Antitumor Mechanisms of Cantharidin and Its Derivatives

作　　者：娄田田[1,2] 杜娟[2] 陈祥盛[2] 李尚伟[2] 

机构地区：[1]贵州大学生命科学学院,贵州贵阳550025 [2]贵州大学昆虫研究所贵州山地农业病虫害重点实验室,贵州贵阳550025

出　　处：《亚太传统医药》2012年第10期205-207,共3页Asia-Pacific Traditional Medicine

基　　金：贵州省优秀科技教育人才省长专项资金项目(15001B-10)

摘　　要：斑蝥素具有抗癌作用,但其毒副作用较大,受限于临床应用。人工合成的斑蝥素衍生物作为一种新型抗癌药物,既保留了斑蝥素的抗肿瘤作用,又减轻了斑蝥素的毒副作用,应用于临床。综述了斑蝥素及其衍生物(去甲斑蝥素、斑蝥酸钠、去甲斑蝥酸钠等)的抗肿瘤机制,为人类更好地利用斑蝥素资源提供理论基础。Objective： Cantharidin has anticancer effects; however, clinical application of cantharidin is limited because of its strong toxicity. Synthetic cantharidin derivatives are a class of novel anticancer drugs used in clinical application, which retain antitumor effects and reduce the side effects of eantharidin. In this paper, we summarized research progress on the antitumor mechanisms of the cantharidin and its derivatives, such as norcantharidin, sodium cantharidate, and sodium demethylcantharidate, in order to pro- vide a theoretical basis for mankind to make better use of cantharidin resources.

关 键 词：斑蝥素 斑蝥素衍生物 抗肿瘤机制 

分 类 号：R285[医药卫生—中药学]