三聚氰胺对肉鸡的急性口服毒性和蓄积毒性  

Acute Oral Toxicity and Accumulative Toxicity of Melamine in Broiler Chickens

作　　者：苏强[1] 朱连勤[1] 朱风华[1] 陈甫[1] 张娇娇[1] 巩青军[1] 

机构地区：[1]青岛农业大学动物科技学院,山东青岛266109

出　　处：《中国兽医杂志》2012年第9期61-63,共3页Chinese Journal of Veterinary Medicine

基　　金：青岛市公共领域科技支撑计划项目(09-1-1-59-nsh)

摘　　要：试验1,选取105羽15日龄AA肉鸡随机分成7个组,每组15羽,分别一次性口服三聚氰胺333.33、436.79、572.35、750.00、982.77、1 287.80mg/kg体重和1 687.50mg/kg体重,观察14d,评价三聚氰胺对肉鸡的急性毒性。结果表明,AA肉鸡口服三聚氰胺的LD50为729.96mg/kg体重,95%可信限为682.08～781.20mg/kg体重。试验2,选取50羽15日龄AA肉鸡随机分成对照组和试验组,每组25羽,试验组肉鸡每日口服三聚氰胺182.49mg/kg体重,累积剂量至5LD50时结束试验,对照组口服等剂量淀粉,评价三聚氰胺对肉鸡的蓄积毒性。试验结束后,对存活肉鸡进行耐受性试验。结果表明,蓄积系数K>5。蓄积毒性试验中存活的鸡一次口服三聚氰胺729.96mg/kg体重后,死亡率达12.5%;对照组肉鸡初次口服三聚氰胺729.96mg/kg体重后,死亡率达52%,两者差异显著(Χ2=8.69,P<0.01)。由此可见,三聚氰胺对肉鸡具有低毒性和轻度蓄积毒性,肉鸡对三聚氰胺有较高的耐受性。Experiment one to observe the acute and accumulative toxicity of melamine in broiler chick ens, one hundred and five broiler chickens were divided randomly into seven groups which were orally ad ministered melamine at 333.33, 436.79, 572.35, 750.00, 982： 77, 1287.80 and 1687.50 mg/kg. bw, re spectively, and observed for 2 weeks and then the acute toxicity of melamine in broiler chickens were eval uated. The results showed that the LDs0 of melamine was estimated to be 729.96 mg/kg . bw in broiler chickens, and the 95% confidence limits were 682.08-781.20 mg/kg . bw. Experiment two, fifty broiler chickens were divided randomly into experimental and control groups. The experimental group was orallyadministered with 182.49 mg/kg .bw daily until the integrating dose reached 5 LD50. The control group was treated with the same dose of starch. After accumulative toxicity test, the melamine poisoning survivors were orally administered melamine with 729, 96 mg/kg . bw to observe tolerance. The results showed that the accumulative coefficient （K） was greater than five. Mortality of the melamine poisoning survivors was 12.5% after orally administered melamine with 729.96 mg/kg . bw, However mortality of the control group was 52%. The difference of both was significant（X2 =8.69,P〈0.05）. Thus, the melamine toxicity to broiler chickens is lower, accumulative toxicity is mild, and broiler chickens have high tolerance of melamine.

关 键 词：三聚氰胺 肉鸡 急性毒性 蓄积毒性 

分 类 号：S858.31[农业科学—临床兽医学]