固-液相转移催化合成1-氰基环丁烷-1-羧酸乙酯  

Solid-liquid Phase-tranfercatalytic Synthesis of 1-cyanocyclobutane-1-ethylacetate

作　　者：宋瑞峰[1] 王玉红[1] 

机构地区：[1]苏州铁道师范学院化学系,苏州215009

出　　处：《铁道师院学报》2000年第3期47-50,共4页Journal of Suzhou Railway Teachers College(Natural Science Edition)

摘　　要：以PEG6 0 0为相转移催化剂 ,无水碳酸钾为碱 ,1 ,2 -二氯乙烷为溶剂 ;氰基乙酸乙酯和 1 ,3-二溴丙烷为反应原料 ,经缩合反应较高产率的合成 1 -氰基环丁烷- 1 -羧酸乙酯 ,收率达 6 4 % ,此方法反应条件温和 ,原料便宜易得 ,操作简便安全。cyanocyclobutane-1-ethylacetate was synthesized in good yield(64%)from the reaction of ethylcyanoacetate with 1,3-dibromopropane using PEG600 as a phase-transfer catalyst,anhydrous potassium as base and 1,2-dichlroethane as solvent. Advantages of the present method are the excellent yields,mild reaction conditions,and operational simplicity.

关 键 词：合成 1-氰基环丁烷-1-羧酸乙酯 固液相转移催化 

分 类 号：O623.624.1[理学—有机化学]