手性α-氰基丙烯酸酯类化合物的合成及生物活性研究  

Study on Synthesis and Bioactivity of Chiral α-Cyanoacrylate Compounds

作　　者：张慧苹[1] 姜琳琳[1] 

机构地区：[1]济宁学院化学与化工系,山东济宁273115

出　　处：《化学与生物工程》2012年第10期51-53,共3页Chemistry & Bioengineering

基　　金：济宁学院青年科研基金项目(2011QNKJ11)

摘　　要：α-氰基丙烯酸酯类化合物是一类抑制植物光合作用PSⅡ的重要除草剂,引入手性因素可以提高其活性。以氰基乙酸乙酯为原料,合成了3-对三氟甲基苯胺-3-(R/S)-α-甲基苄胺-2-氰基丙烯酸酯,对中间体及目标化合物进行了结构表征;并对α-氰基丙烯酸酯类化合物的生物活性进行了研究。结果表明,该类化合物除草活性不突出,但具有一定的抗烟草花叶病毒活性及抗癌活性,具有深入研究的价值。a-Cyanoacrylate is a kind of important herbicide targeted in photosystem PSⅡ. Introduction ot chiral factor can improve its activity. Using cyano ethyl acetate as raw material, ethyl 3-（R/S）-l-phenylethyl- amino-3-（4-（trifluoromethyl）-phenylamino）-2-cyanoacrylate were synthesized. The intermediates and the target compounds were characterized, and the bioactivities of chiral a-cyanoacrylate compounds were determined. The results showed that herbicidal activity of chiral a-cyanoacrylate compounds were not prominent,but they had a certain resistance activity to tobacco mosair virus and anti-cancer activity.

关 键 词：Α-氰基丙烯酸酯 手性 反应机理 生物活性 

分 类 号：TQ225.24[化学工程—有机化工]