基于微电子神经桥实现大鼠运动功能重建的实验研究  

Experimental research on rebuilding motive functions of rat using microelectronic neural bridge

作　　者：沈晓燕[1,2] 王志功[2] 吕晓迎[3] 姜正林[4] 赵鑫泰[2] 黄宗浩[2] 

机构地区：[1]南通大学电子信息学院,南通226019 [2]东南大学射频与光电集成电路研究所,南京210096 [3]东南大学生物电子学国家重点实验室,南京210096 [4]南通大学航海医学研究所,南通226001

出　　处：《东南大学学报（自然科学版）》2012年第5期843-847,共5页Journal of Southeast University：Natural Science Edition

基　　金：国家自然科学基金资助项目(90707005;61001046);江苏省高校自然科学研究计划资助项目(11KJB510022;11KJB510023);东南大学生物电子学国家重点实验室开放研究基金资助项目(2011E05)

摘　　要：设计了一种大鼠神经信道桥接、信号再生和功能重建的实验方案.首先对脊髓适当位置进行功能电激励,诱发控制左腿动作的坐骨神经信号;然后,将此信号作为微电子神经桥的信号源,经微电子神经桥放大处理后施加于离断的右腿坐骨神经远端,从而使瘫痪的右腿产生动作.对控制左腿动作的坐骨神经信号和再生后的右腿神经信号进行相关性分析,结果表明,与再生前的信号相比,再生后的信号在时间上存在延迟,且两者的相干函数值为0.89,符合因果关系.这种设计方案既避免了因生物体组织传导可能引入的伪迹,又克服了因控制运动的神经信号中编、解码未知所造成的困难;此外,运用控制动作的原始神经信号作为控制信号源,使重建更精细、协调的动作行为成为可能.An experimental scheme is designed to realize the rat＇ s sciatic nerve bridge, signal regen- eration and function rebuilding. First, by functional electrical stimulation at the proper sites of spinal cord, sciatic nervous signals related to the movements of the left leg are evoked and used as the sig- nal sources of the microelectronics neural bridge （MENB）. Then, the signals that are amplified and processed by MENB are supplied on the distal stump of the right interrupted sciatic nerve, and move- ments are regenerated. The relationships between the source nervous signals and the regenerated nervous signals are investigated by using coherence analysis. The results show that the regenerated nervous signals are delayed in relation to the source nervous signals and the cross-correlation function reaches the value of 0. 89, which are consistent with causality. This special experimental scheme can not only avoid the artifact introduced by transmission of organization, but also overcome the difficul- ties owing to the unknown of the coding and decoding of the neural signals which control move- ments. Besides, precise and coordinated movements can be rebuilt when the original nervous signals are used as the source signals to control the objective limb.

关 键 词：微电子神经桥 神经功能重建 信号再生 相干性分析 

分 类 号：TN4[电子电信—微电子学与固体电子学] Q426[生物学—神经生物学]