特发性血小板减少性紫癜外周血B1细胞水平变化与病情和预后的关系  

Changes in peripheral blood B1 cell level in patients with idiopathic thrombocytopenic purpura and its relationship with prognosis of the disease

作　　者：张崇林 

机构地区：[1]广西桂林市妇女儿童医院检验科,广西桂林541001

出　　处：《海南医学院学报》2012年第10期1415-1417,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(112210347)~~

摘　　要：目的:研究特发性血小板减少性紫癜外周血B1细胞水平变化与病情和预后的关系。方法:收集在我院就诊的特发性血小板减少性紫癜患者的临床资料,检测患者体内B淋巴细胞总数、CD5+淋巴细胞、外周血中血小板计数,并用SPSS软件进行统计学分析。结果:ITP患者外周血中PLT计数明显少于健康者、B1淋巴细胞百分比明显高于健康者(P<0.05)。初治组ITP患者中有效者在治疗后PLT计数明显升高、B1淋巴细胞百分比明显下降(P<0.05)。难治组ITP患者经过抗H.pylori治疗后血小板计数有一定程度升高、B1淋巴细胞百分比略有降低(P<0.05)。结论:B1淋巴细胞水平的升高和ITP的发生密切相关,特别是pylori感染引起的B1淋巴细胞水平升高会导致难治性ITP的发生。Objective. To explore the relationship between peripheral blood B1 cell levels and se- verity and prognosis in patients with idiopathic thrombocytopenic purpura. Methods. Clinical data of idiopathic thrombocytopenie purpura patients were colleeted; total number of in vivo B lymphocyte, CD5 ＋ lymphocytes, platelet counts in peripheral blood were counted and analyzed by SPSS software. Results： PLT counts of idiopathic thrombocytopenie purpura patients was significantly less than that of healthy person while B1 lymphocyte percentage was higher （P〈0.05）. PLT counts were increased, and B1 lymphocyte percentage were reduced in patients that were improved after initial treatment （P〈0.05）, while increase of PLT counts and reduce in B1 lymphocyte percentage were not very obvious for refractory patients though they were given Anti-Helicobacter pylori treatment （P〈0.05）. Conclusion： Increase of B1 lymphocyte levels are closely related with the occurrence of idiopathic thrombocytopenic purpura, especially increase of B1 lymphocyte levels caused by Helicobacter pylori infections may lead to refractory idiopathic thrombocytopenic purpura.

关 键 词：特发性血小板减少性紫癜 B1细胞 CD5+ 预后 

分 类 号：R72[医药卫生—儿科]