感染相关性胆汁淤积症患者内毒素测定的临床意义及痰热清的清除作用  

Clinical significance of determination of serum endotoxin in sepsis-associated cholestasis patients and clearance effect of Tanreqing

作　　者：李智[1] 李健[2] 樊和斌[1] 徐礼通[1] 周昊[1] 田展飞[1] 刘靖[3] 

机构地区：[1]解放军161医院感染科,湖北武汉430010 [2]解放军161医院放疗中心,湖北武汉430010 [3]解放军161医院儿科,湖北武汉430010

出　　处：《中华医院感染学杂志》2012年第19期4248-4250,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析感染相关性胆汁淤积患者血清内毒素水平、临床意义以及痰热清对内毒素的清除作用。方法对42例明确诊断为感染相关性胆汁淤积症的患者进行内毒素测定,比较治疗前及病情好转后血清内毒素水平变化情况;同时以25例明确存在感染但未出现胆汁淤积的患者作为对照组,比较两组之间内毒素水平。结果 42例感染相关性胆汁淤积症患者治疗前血清内毒素水平(65.83±22.12)pg/ml,对照组为(15.05±3.02)pg/ml,两组差异有统计学意义(P<0.05),治疗后血清内毒素水平(32.32±10.21)pg/ml,治疗后明显低于治疗前,差异有统计学意义(P<0.05);老年及有基础疾病患者更容易发生感染相关性胆汁淤积症。结论内毒素是细菌感染患者出现胆汁淤积的重要因素之一,痰热清对内毒素具有较强的清除作用,对于机体免疫力低的患者,及早行内毒素水平的测定,尽快行护肝、退黄治疗,可以改善预后,缩短病程,具有重要的临床意义。OBJECTIVE To analyze the level of serum endotoxin in sepsis-associated cholestasis patients and its clinical significance and the effect of Tanreqing injection on the clearance of endotoxin.METHODS Meanwhile,25 infected patients without cholestasis were included in the control group.The levels of the serum of endotoxin were compared between the two groups.RESULTS The level of serum endotoxin in the 42 sepsis-associated cholestasis patients was（65.83±22.12）pg/ml before the treatment,（15.05±3.02）pg/ml in the control group,the difference was statistically significant（P0.05）.CONCLUSION Endotoxin is one of the important factor to develop cholestasis in the patients with the bacterial infections.Tanreqing has a strong effect on clearance of endotoxin.For the immunocompromised patients,it is of great clinical significance in improving the prognosis and shortening the course of disease to perform the determination of the serum endotoxin and liver protection by medication in a timely manner.

关 键 词：感染 胆汁淤积 内毒素 

分 类 号：R181.32[医药卫生—流行病学]