193株嗜麦芽寡养单胞菌的临床特点及药敏分析  

Clinical characteristics and drug susceptibility of 193 strains of Stenotrophomonas maltophilia

作　　者：傅欢泉[1] 

机构地区：[1]杭州市萧山区第一人民医院检验科,浙江杭州311201

出　　处：《中华医院感染学杂志》2012年第19期4362-4364,共3页Chinese Journal of Nosocomiology

摘　　要：目的研究嗜麦芽寡养单胞菌的临床特点和耐药性。方法采用VITEK-2全自动微生物鉴定仪对193株嗜麦芽寡养单胞菌进行分离鉴定与药敏试验,并对其标本来源、科室分布和耐药性进行回顾性分析。结果 193株嗜麦芽寡养单胞菌标本来源以痰液最多,占91.7%,其次为尿液,占4.1%;科室分布以ICU最高,占59.6%,其次为呼吸内科及神经内科,占15.0%、12.4%;嗜麦芽寡养单胞菌对左氧氟沙星和磺胺甲噁唑/甲氧苄啶敏感性较高,其敏感率分别为83.4%和78.8%,而对头孢唑林、头孢曲松、阿莫西林、呋喃妥因、亚胺培南、氨曲南和氨苄西林/舒巴坦耐药性较高,耐药率为92.2%～99.0%;对哌拉西林/他唑巴坦虽敏感率为44.6%,但中介率达41.9%。结论嗜麦芽寡养单胞菌对多种临床常见抗菌药物呈现不同程度的耐药,加强耐药性监测,为合理经济用药提供理论依据具有重要的参考价值。OBJECTIVE To study the clinical characteristics and drug resistance of Stenotrophomonas maltophilia.METHODS A total of 193 strains of S.maltophilia were identified and evaluated by VITEK-2 system.The specimen sources,department distribution and drug resistance were reviewed retrospectively.RESULTS Of 193 strains of S.maltophilia isolated,most of which were isolated from sputum（91.7%）,followed by the urine（4.1%）;the isolates were mainly from ICU（59.6%）,respiratory medicine department（15.0%） and department of neurology（12.4%）;the drug susceptibility rates of S.maltophilia to levofloxacin and trimethoprim/sulfamethoxazole were 83.4% and 78.8%,respectively,and the antimicrobial resistance rates to cefazolin,ceftriaxome,imipenem,nitrofurantoin,aztreonam,ampicillin/sulbactam varied from 92.2% to 99.0%;the drug susceptibility rate to piperacillin/tazobactam was 44.6%,however,the intermediate rate was up to 41.9%.CONCLUSION S.maltophilia varies in drug resistance to many common clinical antibiotics;to strengthen the surveillance of drug resistance can provide theoretical basis for reasonable use of antibiotics.

关 键 词：嗜麦芽寡养单胞菌 医院感染 耐药性 

分 类 号：R378[医药卫生—病原生物学]