腹腔常频和高频喷射给氧对急性呼吸窘迫综合征家犬低血氧的改善效果  

The effects of high and conventional frequency peritoneal jet ventilation on hypoxemia in ARDS dogs

作　　者：李浩[1] 陆利冲[1] 李文媛[1] 汪小海[1] 

机构地区：[1]南京大学医学院附属鼓楼医院麻醉科,210008

出　　处：《临床麻醉学杂志》2012年第9期908-911,共4页Journal of Clinical Anesthesiology

摘　　要：目的观察经腹腔常频喷射通气(CFJV)和高频喷射通气(HFJV)给氧对急性呼吸窘迫综合征(ARDS)家犬低血氧的改善效果。方法 15只家犬常规麻醉后在温盐水肺灌洗诱发ARDS模型后,将实验动物随机均分为三组,分别为对照组(C组)、CFJV组和HFJV组,并进行各组相应处理。观察三组建模前(T0)、建模时(T1)、建模后15min(T2)、30min(T3)、60min(T4)、90min(T5)、120min(T6)时动、静脉血氧分压、电解质、HR、MAP的变化。结果与T0时比较,T1时三组PaO2、PvO2明显降低、PaCO2明显升高(P<0.05)。与C组比较,T2～T6时HFJV组、T2和T3时CFJV组PaO2明显升高(P<0.05);T2～T4时HFJV组PaCO2和T3～T6时HFJV组和CFJV组PvO2明显升高(P<0.05)。与CFJV组比较,T5、T6时HFJV组PaO2明显升高(P<0.05)。三组电解质、HR、MAP差异均无统计学意义。结论腹腔CFJV和HFJV给氧对急性肺损伤家犬低血氧均有显著改善效果。Objective To observe the effect of high and conventional frequency peritoneal jet ventilation on hypoxemia in ARDS dogs. Methods Fifteen anesthetized dogs were given preheated saline lavage to achieve ARDS and then randomly divided into three groups（n= 5, each）： control group （group C）, conventional frequency group（group CFJV）, and high frequency group（group HFJV）, and received appropriate treatment in each group. Arterial and mixed venous blood gas analysis were performed. PaO2 ,PvO2, electrolyte, HR and MAP were observed in all groups before（T0 ） and 0 min （Tl）, 15 min（T2 ）, 30 min（T3 ）, 60 min（T4 ）, 90 min（T5 ）, 120 min（T6 ） after the establishment of model. Results To compare with To, the PaO2 and PvO2 were significantly decreased, but PaCO2 was significantly increased at T1 in three groups（P〈0.05）. To compare with group C, PaO2 in group HFJV was increased at T2-T6 and also increased in group CFJV at T2 ,T3 （P〈0. 05） ;PaCO2 in group HFJV was increased at T2-T4. PvO2 in group HFJV and group CFJV were increased at T3-T6 （P〈 0.05）. To compare with group CFJV, PaO2 in group HFJV was increased at T5 ,T6 （P〈0.05）. The electrolyte, HR and MAP had no obvious change in three groups. Conclusion Conventional and high frequency peritoneal jet ventilation can both markedly improve the oxygenation of ARDS dogs.

关 键 词：家犬 腹膜氧合 急性呼吸窘迫综合征 喷射通气 

分 类 号：R563.8[医药卫生—呼吸系统]