参附注射液对多发创伤并发休克患者凝血功能的影响  

The effection of Shenfu Injection （Ginseng-radix aconitum Injection） to the coagulation in the patient of multiple trauma complicated with shock

作　　者：蒋国平[1] 文怀[1] 雷李美[2] 楼天正[2] 许伟海[2] 

机构地区：[1]浙江大学医学院附属第二医院急诊中心,杭州310009 [2]温州医学院附属第六医院/浙江省丽水市人民医院急诊科

出　　处：《中华急诊医学杂志》2012年第10期1127-1129,共3页Chinese Journal of Emergency Medicine

摘　　要：目的探讨应用参附注射液对多发创伤并发休克患者凝血系统及其对预后的影响。方法2007年2至2011年12月间前瞻性研究浙江大学医学院附属第二医院急诊科90例多发创伤合并休克的患者（排除创伤前有凝血功能障碍者和出血未确定性控制者），按随机（随机数字法）原则分为两组：治疗组（45例）和对照组（45例）。对照组给予常规综合治疗，治疗组在常规综合治疗基础上早期加用参附注射液50ml＋生理盐水100ml静脉滴注，1次/12h，连续7d;分别检测2组伤后治疗前、治疗后3、7d的血小板计数（PLT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（FIB），并作统计分析。结果对照组与治疗组间年龄、性别、创伤严重度比较无统计学意义，治疗组于治疗3、7d后上述检测指标改善，且与对照组比较差异有统计学意义（P〈0.05）。结论应用参附注射液对严重多发创伤并发休克患者凝血系统有良性调节作用。Objective To investigate the effection of Shenfu Injection （ Ginseng-radix aconitum Injection） to the blood coagulation system and its prognosis in the patient of multiple trauma complicated with shock. Methods We prospectively studied 90 patients of multiple trauma complicated with shock,who came from the emergency center of the Second Affiliated Hospital of Medicine ’ s college of Zhe-Jiang University and emergency department of Lishui People’s Hospital from February 2007 to December 2011,and excluded those suffered with the dysfunction of coagulation system and uncontrolled ongoing bleeding before trauma. And then these eligible patients were randomly divided into two groups： treatment group 〈 45 cases ） and control group （45 cases）,the control group were received the routine treatment, the treatment group were received Shenfu Injection in early stage based on the routine treatment. The two groups -were measured the platelet count （ PLT） , prothrombin time （ PT） , activated partial thromboplastin time （ APTT） , thrombin time （IT） , fibrinogen （FIB） before treatment and 3,7 days after treatment. Results The differences of the PLT,PT,APTT,TT,FIB between the treatment group and control group at 3 , 7 d after the treatment was statistically significant （ P 〈 0. 05 ）. Conclusions Shenfu Injection has positive regulation to the coagulation system in the patient of multiple trauma complicated with shock.

关 键 词：参附注射液 多发伤 休克 凝血系统 

分 类 号：R641[医药卫生—外科学]