水溶性白藜芦醇衍生物的制备及其性质研究  

Study on the Preparation and Characterize of Water-soluble Resveratrol Deviates

作　　者：叶峰[1] 黄鹏[1] 卞海洋[1] 张静[1] 张丽君[1] 

机构地区：[1]安徽中医学院药学院,安徽合肥230031

出　　处：《广东化工》2012年第14期25-26,共2页Guangdong Chemical Industry

基　　金：安徽中医学院药学院药苑之星项目(2011)

摘　　要：为了增强白藜芦醇(1)的水溶性和抗肿瘤的靶向性,通过DCC/DMAP偶联法,分别将葡萄糖和1引入两端均羧基化的聚乙二醇两端构建葡萄糖-聚乙二醇支载白藜芦醇衍生物,其结构经1H-NMR和IR表征;采用UV法测定产物中白藜芦醇的含量及水溶性。结果表明,由PEG4000支载的葡萄糖-聚乙二醇-白藜芦醇的水溶性最好。In order to enhance the targeting of resveratrol（1） water-soluble and anti-tumor,glucose and 1 were conjugated into chain segment of carboxylated PEG by DCC/DMAP cross linking to construct Glu-PEG-1（4）.The structures were charactered by 1HNMR and IR;UV method for the determination of the content of resveratrol in the product and water-soluble.The results showed that PEG4000-supported glucose-PEG-Resveratrol has the best water-soluble.

关 键 词：白藜芦醇 聚乙二醇 合成 水溶性 

分 类 号：TQ221.223[化学工程—有机化工]