新的天然免疫保护分子SPLUNC1的结构与功能研究进展  

The Structure and Function of SPLUNC1:Novel Class of Innate Immune Protective Molecules

作　　者：郭小芳[1] 陈攀[1] 李夏雨[1] 李小玲[1] 李桂源[1] 

机构地区：[1]中南大学肿瘤研究所,长沙410078

出　　处：《生物化学与生物物理进展》2012年第10期945-951,共7页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金资助项目(81101509;81171930)~~

摘　　要：腭、肺及鼻咽上皮克隆(palate,lung,and nasal epithelium clone,PLUNC)家族为一新近发现的具有宿主防御功能的蛋白质家族,它们大多存在于呼吸道上皮与消化道上皮的表面,在上皮组织与外界各种信号之间起着信号传递中介与信号执行分子的作用.在迄今为止发现的人类10个PLUNC家族成员中,我们所克隆的NASG基因即为这一免疫保护分子家族的成员,对其结构与功能分析表明,它属于SPLUNC1(short palate,lung,and nasal epithelium clone 1)的全新转录本,具有杀菌/渗透增强蛋白质结构域,能对外来物理及化学刺激做出反应,并具有抗微生物、清除有害化学物质、抗肿瘤等多重功效.SPLUNC1作为上呼吸道的一种新的天然免疫保护分子,在维持上呼吸道的正常生理活动以及抗炎杀菌抑瘤中起着重要作用.Epithelial surfaces of the upper alimentary tract and upper respiratory tract are swarming with protein compounds that protect itself from many kinds of damages. These compounds are consisted of innate immune molecules. From the structure and functional prediction, the new member is added, PLUNC family, to the compounds. They are including at least ten members. SPLUNC 1 （short palate, lung, and nasal epithelium clone 1） is isolated from human nasopharyngeal epithelia by suppression subtractive hybridization （SSH） and cDNA microarray analysis in our lab. SPLUNC 1 is a gene transcript of the PLUNC gene family and also is a member of the BPI （bactericidal permeability increasing protein）/LBP （lipopolysaccharide-binding protein） family with putative bactericidal/bacteriostatic functions. They may function to protect epithelial surfaces from pathogenic micro-organism and harmful gases, the wrong expression will lead to host tissues destruction and tumorigenesis.

关 键 词：SPLUNC1 上呼吸道 天然免疫保护分子 

分 类 号：Q78[生物学—分子生物学]