雌四醇监测胎儿的探讨  

Estetrol in monitoring fetal well-being

作　　者：张全[1] 刘建立[1] 霍秀勤[1] 王志清[2] 王作华[2] 骆传环[2] 

机构地区：[1]解放军总医院妇产科 [2]军事医学科学院放射医学研究所

出　　处：《军医进修学院学报》1990年第1期60-61,共2页Academic Journal of Pla Postgraduate Medical School

摘　　要：雌四醇(E_4)是胎儿肝脏合成的甾体化合物,是评价胎儿在宫内生长发育的一项敏感指标。本文利用气相色谱法测定了48名孕妇尿中E_4含量,16例正常妊娠、1例轻度、2例中度妊高征和1例妊娠39^(+2)周合并贫血的孕妇尿中测到了E_4;另20例正常妊娠、3例轻度、1例中度、3例重度妊高征和1例无脑儿孕妇尿中未测到E_4。 20例孕妇尿中E_4阳性胎儿发育良好,无畸形或死胎,平均体重3388±487克;而28例孕妇尿E_4阴性,娩出2例多发畸形儿、1例无脑儿和1例胎龄小样儿,平均体重为3015±553克,统计学检验两组间差别显著(P<0.05)。Estetrol (E4) has been suggested to be used as a sensitive indicator of fetal well-being. The determiantion of E4 in the urine of 48 pregnant women by Gas chromatograph is reported. 20 (?)rine samples, 16 from normal pregnancies, 1 from mild, and 2 from moderate pregnancy hypertension and 1 from pregnancy anemia were examined, of which 6.8g% were found to have E4. 28 urine samples, 20 from normal pregnant women, 3 from mild, 1 from moderate, 3 from severe preeclampsia and 1 from anencephaly, did not show E4. They gave birth to 2 babies with multiple anormalies, 1 with anencephaly and 1 IUGR weighing 1150g. The average body weight of the babies in the positive and negative groups were 3388±487g and 3015±553g respectively. This difference is statistically significant (P<0.05).

关 键 词：雌四醇 胎儿监测 胎儿器官成熟 

分 类 号：R714.5[医药卫生—妇产科学]