胸、腹腔积液中纤维连结蛋白测定的诊断价值  

Diagnostic value of fibronectin (FN) cocentration in pleural or abdominal fluid

作　　者：张进川[1] 王淑敏[1] 李峻亨[1] 梁平[2] 张晓平[2] 张遵一[2] 

机构地区：[1]中国人民解放军军医进修学院呼吸科 [2]中国人民解放军军医进修学院免疫室

出　　处：《军医进修学院学报》1990年第2期130-131,共2页Academic Journal of Pla Postgraduate Medical School

摘　　要：本文用免疫扩散法测定了73例胸(64例)或腹(9例)水纤维连结蛋白(FN)浓度。33例恶性胸水中的FN为648.18±188.83μg/ml(X±SD),3l例结核性胸水FN432.45±109.91μg/ml和9例肝硬化腹水中FN为191.78±22.26μg/m1。本组显示FN在恶性疾病组最高,在肝病,特别是肝硬化,FN值降低,指示胸、腹水中FN的测定,在疾病的鉴别诊断中具有意义。The differential diagnosis between malignant and benign diseases with pleural or abdominal fluid is A common clinical problem. 73 specimens of pleural (64 cases) or abdominal (9 cases) fluid hare been examined for FN by immunodiffusion method. In 33 cases of malignant disease, the FN in pleural fluid was 648.18 ± 188.83 ug/ml (mean±SD), in 31 cases of tuberculosis, 432.45± 109.91 ug/ml, and in 9 cases of cirrhosis the FN in asites was 191.78± 22.26 ug/ml. The results suggest that increased FN concentration reflects the presence of malignant disease, and in liver disease, particularly in cirrhosis, the FN concentration is lowered. So, it is believed that assay of FN in pleural and abdominal fluid may be useful in the differential diagnosis of diseases such as neoplasm.

关 键 词：纤维连接素类 胸膜积液 腹水液 肿瘤 诊断 

分 类 号：R561.404[医药卫生—呼吸系统]