中心性浆液性脉络膜视网膜病变的脉络膜厚度改变  

Changes of choroidal thickness in central serous chorioretinopathy

作　　者：杨丽红[1] 田蓓[1] 史雪辉[1] 丁宁[1] 周丹[1] 魏文斌[1] 

机构地区：[1]首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室,100730

出　　处：《中华眼科杂志》2012年第10期874-877,共4页Chinese Journal of Ophthalmology

基　　金：北京市卫生系统高层次卫生技术人才培养计划（2009-3-32）;北京市优秀人才基金（20041190300312）

摘　　要：目的定量分析中心性浆液性脉络膜视网膜病变（CSC）患者黄斑中心凹下脉络膜厚度改变。方法横断面研究。选择经荧光素眼底血管造影（FFA）、吲哚氰绿血管造影（ICGA）、脉络膜深层成像相干光断层扫描（EDI—OCT）检查后，确诊的23例单眼CSC患者作为研究对象；以年龄、性别、屈光状态与CSC组相匹配的23例正常人作为对照。应用EDI—OCT技术及仪器内白带软件检测患者组和对照组黄斑中心凹下脉络膜厚度。患者组患眼与对侧眼脉络膜厚度比较，采用配对t检验；患者组患眼和对侧眼脉络膜厚度分别与对照组比较（非正态分布），采用独立样本秩和检验，并以Bonferroni法进行校正。结果CSC患者组的患眼黄斑中心凹下脉络膜厚度为（464．434-97．15）μm，对侧眼为（399．91±124．01）μm，两者差异有统计学意义（t=4．653，P〈0．05）。正常对照组黄斑中心凹下脉络膜厚度为（313．09±70．67）μm，患者组的患眼和对侧眼脉络膜厚度分别与正常对照组比较，差异有统计学意义（t=5．077，-2．085；P〈0．05）。患眼的对侧眼中ICGA高灌注眼脉络膜厚度为（506．444-75．66）μm，非高灌注眼为（331．434-97．94）Ixm，两者差异有统计学意义（t=4．749，P〈0．05）。结论CSC患者的患眼脉络膜厚度较对侧眼及对照组增厚，对侧眼中ICGA高灌注眼的脉络膜厚度较非高灌注眼增厚。EDI—OCT检测技术是观察脉络膜血管通透性改变的无损伤手段之一。（中华眼科杂志．2012，48：874-877）Objective To determine the quantitative changes of choroidal thickness in central serous chorioretinopathy. Methods Cross-sectional study. Twenty-three patients with unilateral central serous chorioretinopathy （CSC） in acute and chronic stages were diagnosed after fluorescein angiography, indocyanine angiography and enhanced depth imaging optical coherence tomography （EDI OCT）. EDI OCT scan across the fovea was performed in each eye and the result was compared with that from an age-, sex- matched and spherical equivalent-matched control subject. Subfoveal thickness of choroid was calculated by a onboard software in HRA2. Results Choroidal thickness in the CSC eyes and the fellow eyes was （464. 43 ± 97. 15） μm and（399. 91± 124. 01 ） μm, respectively. No significant difference between the two groups （t = 4. 653, P 〈 0. 05 ）. Choroidal thickness was （313.09 ± 70. 67 ） μm in the control group. There was statistically significant difference in thickness between the CSC goup and the control group （ t = 5. 077, -2. 085 ;P 〈 0. 05）. Choroidal thickness in the fellow eyes with choroidal vascular hyperpermeability was （506. 44 ± 75.66） μm, which was differed significantly （ t = 4. 749, P 〈 0. 05 ） from the non-hypermeability eyes （331.43 ± 97.94） μm. Conclusions Subfoveal choroid thickness in the symptomatic eye and the fellow eyes in CSC gruoup is thicker than that of the control group. The subfoveal choroidal thickness of eyes with hypermeability is thicker than that in the non-hypermeability eyes. EDI-OCT is a noninvasive procedure which can be used to evaluate the choroidal hypermeability in CSC. （Chin J Opbthalmol, 2012,48：874- 877）

关 键 词：中心性浆液性脉络膜视网膜病变 体层摄影术 光学相干 脉络膜 

分 类 号：R774.1[医药卫生—眼科]