脓毒症患者血清IL-6与脑损伤的相关性分析  

Correlation analysis between serum interleukin-6 and central nervous injury in septic patients

作　　者：刘占国 谭晓莹[1] 蔡靓 杨祥锐[1] 常平[1] 

机构地区：[1]南方医科大学珠江医院重症医学科,广东广州510282

出　　处：《南方医科大学学报》2012年第10期1451-1453,共3页Journal of Southern Medical University

基　　金：国家自然科学基金(81101451);广东省自然基金(S2011010003106);广东省医学科学技术研究基金(B2011208)~~

摘　　要：目的探讨脓毒症患者血清白细胞介素-6(IL-6)水平与中枢神经损伤的关系。方法选择符合脓毒症诊断标准同时无中枢神经系统疾病的患者22例作为研究对象,检测血清IL-6和神经元特异性烯醇化酶(NSE)水平,并根据IL-6的水平分为低中高3个浓度组,比较3个浓度组NSE水平及急性生理和慢性健康(APACHEII)评分的差异,分析血清IL-6与NSE及APACHEII的相关性。结果 IL-6低中高3个浓度组NSE水平具有显著性差异(P<0.001),浓度分别为(10.29±4.05)、(16.06±5.84)、(23.97±3.28)μg/L。IL-6三个浓度组的APACHEII评分同样具有显著性差异(P=0.009),分值分别为14.17±4.67、16.40±4.84和24.00±6.26。相关性分析显示IL-6与NSE和APACHEII评分均具有显著的正相关性,相关系数分别为r=0.788(P<0.001)和0.733(P<0.001)。结论脓毒症患者血清IL-6的浓度同患者危重程度和中枢神经损伤均有显著地相关性,可以作为动态监测脓毒性脑损伤的标志物。Objective To explore the relationship between interleukin-6（IL-6） production and central nervous injury in septic patients.Methods Twenty-two septic patients without central nervous system diseases were examined for serum IL-6 and neuron-specific enolase（NSE） levels,and the serum NSE levels and APACHEII scores were compared between patients with low,moderate,and high serum IL-6 levels.The correlations between NSE,APACHEII and serum IL-6 were analyzed.Results In patients with low,moderate,and high serum IL-6 levels,the serum levels of NSE were 10.29±4.05,16.06±5.84 and 23.97±3.28 μg/L,respectively,showing a significant difference between the 3 groups（P0.001）.The APACHEII scores also differed significantly between the 3 groups（14.17±4.67,16.40±4.84,and 24.00±6.26,respectively,P=0.009）.Correlation analysis showed significant positive correlations of IL-6 with NSE（r=0.788,P0.001） and with APACHEII scores（r=0.733,P0.001）.Conclusion In septic patients,serum IL-6 level is significantly correlated with the severity of sepsis and brain injury,and can be used as a marker to monitor brain injury in septic patients.

关 键 词：脓毒症 脑损伤 IL-6 神经元特异性烯醇化酶 

分 类 号：R459.7[医药卫生—急诊医学]