非胰岛素依赖型糖尿病患者黎明现象的观察  

Dawn phenomenon in NIDDM 10 patients

作　　者：潘长玉[1] 田慧[1] 陆菊明[1] 李晖[2] 

机构地区：[1]中国人民解放军进修学院内分泌科 [2]中国人民解放军进修学院医学数理统计教研室

出　　处：《军医进修学院学报》1990年第3期189-192,共4页Academic Journal of Pla Postgraduate Medical School

摘　　要：本文对10名NIDDM患者(男6例,女4例,平均年龄41.7±5.7岁)的黎明现象进行了观察。受试者在常规饮食和口服药的情况下,于24:00～08:00时每小时抽血一次,测BG、F、GH、GG和InS,并于24:00,03:00,05:00,08:00时分别采血测ACTH。如果按凌晨BG上升至少大于1mmol/L作为黎明现象的判定标准,则本组出现这种现象的频率为6/10。本研究提示,在常规治疗的NIDDM患者中,黎明现象也常见到。胰岛素作用缺乏和对抗激素F升高,可能在黎明现象发生机制中起作用。To assess the dawn phenomenon and its frequency in NIDDM patients on conventional therapy, 10 patients (6 males, 4 females with age of 41.7±5.7 year) were studied. Hourly blood samples were taken from 24:00 to 8:00 h for BG, F, GH, GG and INS. ACTH was measured at 24: 00, 03:00, 05:00 and 08:00 h respectively. If we defined the dawn phenomenon as a rise in early morning BG of>1.0mmol/l, then 6/10 patients in the present group exhibited this phenomenon. Thus the dawn phenomenon occurs commonly in NIDDM patients treated with conventional therapy. This study suggest that the deficiency of insulin and the increased level of couterregulatory hormone-F may pay a role in pathogenesis of the dawn phenomenon in NIDDM patients.

关 键 词：糖尿病 黎明现象 血糖过多 

分 类 号：R587.102[医药卫生—内分泌]